Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43

Y Tanaka, S Ito, Y Honma, M Hasegawa… - Journal of Biological …, 2023 - ASBMB
The cytoplasmic accumulation of the nuclear protein transactive response DNA-binding
protein 43 kDa (TDP-43) has been linked to the progression of amyotrophic lateral sclerosis …

Male‐pronuclei‐specific granulin facilitates somatic cells reprogramming via mitigating excessive cell proliferation and enhancing lysosomal function

Q Wei, Y Xu, G Cui, J Sun, Z Su, X Kou… - Journal of Cellular …, 2024 - Wiley Online Library
Critical reprogramming factors resided predominantly in the oocyte or male pronucleus can
enhance the efficiency or the quality of induced pluripotent stem cells (iPSCs) induction …

[PDF][PDF] 網脈絡膜疾患の病態解明並びに新規治療ターゲットの探索研究

田中美留豊 - 2022 - gifu-pu.repo.nii.ac.jp
外界の光は角膜や硝子体を通過し, 網膜で視細胞に受容されることで視覚情報として伝達される.
網膜はエネルギー需要の高い組織であり, 網膜血管及び脈絡膜血管がその栄養や酸素の供給を …