Tissue fibrosis and extracellular matrix (ECM) stiffening promote tumour progression. The
mechanisms by which ECM regulates its contacting cells have been extensively studied …

Cells respond to mitochondrial poisons with rapid activation of the adenosine
monophosphate–activated protein kinase (AMPK), causing acute metabolic changes …

Dysfunctional autophagy has been implicated in the pathogenesis of Alzheimer's disease
(AD). Previous evidence suggested disruptions of multiple stages of the autophagy …

Stimulator of interferon genes (STING) is an intracellular sensor of cyclic di-nucleotides
involved in the innate immune response against pathogen-or self-derived DNA. STING …

Plots and charts are graphical tools that make data intelligible and digestible by humans. But
the oversimplification of data by only plotting the statistical summaries conflicts with the …

Early-life establishment of tolerance to commensal bacteria at barrier surfaces carries
enduring implications for immune health but remains poorly understood. Here, we showed …

The mechanisms by which exercise benefits patients with non-alcoholic fatty liver disease
(NAFLD), the most common liver disease worldwide, remain poorly understood. A non …

The accumulation of senescent cells is a key characteristic of aging, leading to the
progression of age-related diseases such as osteoarthritis (OA). Previous data from our …

Meningeal lymphatic vessels (MLVs) promote tissue clearance and immune surveillance in
the central nervous system (CNS). Vascular endothelial growth factor-C (VEGF-C) regulates …

Dysregulation of zinc and zinc transporters families has been associated with the genesis
and progression of prostate cancer. The prostate epithelium utilizes two types of zinc …