Oxidative stress in bacteria and the central dogma of molecular biology

M Fasnacht, N Polacek - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Ever since the “great oxidation event,” Earth's cellular life forms had to cope with the danger
of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering …

Small regulatory RNAs in the enterobacterial response to envelope damage and oxidative stress

KS Fröhlich, S Gottesman - … with RNA in Bacteria and Archaea, 2018 - Wiley Online Library
One major paradigm for RNA‐based regulation in both eukaryotes and prokaryotes is small
regulatory RNAs (sRNAs) that pair with mRNAs, leading to changes in translation and …

[HTML][HTML] Phenotypic heterogeneity in the bacterial oxidative stress response is driven by cell-cell interactions

D Choudhary, V Lagage, KR Foster, S Uphoff - Cell Reports, 2023 - cell.com
Genetically identical bacterial cells commonly display different phenotypes. This phenotypic
heterogeneity is well known for stress responses, where it is often explained as bet hedging …

Cannabidiol induces cell cycle arrest and cell apoptosis in human gastric cancer SGC-7901 cells

X Zhang, Y Qin, Z Pan, M Li, X Liu, X Chen, G Qu… - Biomolecules, 2019 - mdpi.com
The main chemical component of cannabis, cannabidiol (CBD), has been shown to have
antitumor properties. The present study examined the in vitro effects of CBD on human …

The global RNA–RNA interactome of Klebsiella pneumoniae unveils a small RNA regulator of cell division

E Ruhland, M Siemers, R Gerst… - Proceedings of the …, 2024 - National Acad Sciences
The ubiquitous RNA chaperone Hfq is involved in the regulation of key biological processes
in many species across the bacterial kingdom. In the opportunistic human pathogen …

Freiburg RNA tools: a central online resource for RNA-focused research and teaching

M Raden, SM Ali, OS Alkhnbashi, A Busch… - Nucleic acids …, 2018 - academic.oup.com
The Freiburg RNA tools webserver is a well established online resource for RNA-focused
research. It provides a unified user interface and comprehensive result visualization for …

Non-lethal exposure to H2O2 boosts bacterial survival and evolvability against oxidative stress

A Rodríguez-Rojas, JJ Kim, PR Johnston… - PLoS …, 2020 - journals.plos.org
Unicellular organisms have the prevalent challenge to survive under oxidative stress of
reactive oxygen species (ROS) such as hydrogen peroxide (H2O2). ROS are present as by …

Cell free bacteriophage synthesis from engineered strains improves yield

R Brooks, L Morici, N Sandoval - ACS Synthetic Biology, 2023 - ACS Publications
Phage therapy to treat life-threatening drug-resistant infections has been hampered by
technical challenges in phage production. Cell-free bacteriophage synthesis (CFBS) can …

Small RNA OxyS induces resistance to aminoglycosides during oxidative stress by controlling Fe–S cluster biogenesis in Escherichia coli

C Baussier, C Oriol, S Durand, B Py… - Proceedings of the …, 2024 - pnas.org
Fe–S clusters are essential cofactors involved in many reactions across all domains of life.
Their biogenesis in Escherichia coli and other enterobacteria involves two machineries: Isc …

The master regulator OxyR orchestrates bacterial oxidative stress response genes in space and time

D Choudhary, KR Foster, S Uphoff - Cell Systems, 2024 - cell.com
Bacteria employ diverse gene regulatory networks to survive stress, but deciphering the
underlying logic of these complex networks has proved challenging. Here, we use time …