Role and therapeutic potential of VEGF in the nervous system

C Ruiz de Almodovar, D Lambrechts… - Physiological …, 2009 - journals.physiology.org
The development of the nervous and vascular systems constitutes primary events in the
evolution of the animal kingdom; the former provides electrical stimuli and coordination …

Retinal macroglial responses in health and disease

R de Hoz, B Rojas, AI Ramírez… - BioMed research …, 2016 - Wiley Online Library
Due to their permanent and close proximity to neurons, glial cells perform essential tasks for
the normal physiology of the retina. Astrocytes and Müller cells (retinal macroglia) provide …

Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage

J Wang, X Xu, MH Elliott, M Zhu, YZ Le - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Vascular endothelial growth factor (VEGF-A or VEGF) is a major pathogenic
factor and therapeutic target for diabetic retinopathy (DR). Since VEGF has been proposed …

VEGF is an autocrine/paracrine neuroprotective factor for injured retinal ganglion neurons

N Froger, F Matonti, C Roubeix, V Forster, I Ivkovic… - Scientific reports, 2020 - nature.com
Vascular endothelial growth factor-A (VEGF) is the angiogenic factor promoting the
pathological neovascularization in age-related macular degeneration (AMD) or diabetic …

Müller cell‐derived VEGF is a significant contributor to retinal neovascularization

Y Bai, J Ma, J Guo, J Wang, M Zhu… - The Journal of …, 2009 - Wiley Online Library
Vascular endothelial growth factor (VEGF-A) is a major pathogenic factor and a therapeutic
target for age-related macular degeneration, diabetic retinopathy, and retinopathy of …

[HTML][HTML] VEGF-A is necessary and sufficient for retinal neuroprotection in models of experimental glaucoma

RH Foxton, A Finkelstein, S Vijay… - The American journal of …, 2013 - Elsevier
Vascular endothelial growth factor A (VEGF-A) is a validated therapeutic target in several
angiogenic-and vascular permeability–related pathological conditions, including certain …

Dual roles of the MAPK/ERK1/2 cell signaling pathway after stroke

N Sawe, G Steinberg, H Zhao - Journal of neuroscience …, 2008 - Wiley Online Library
Abstract Extracellular signal–regulated kinase 1/2 (ERK1/2), one of the best‐characterized
members of the mitogen‐activated protein kinase (MAPK) family, mediates a range of activity …

VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration

P Carmeliet, CR de Almodovar - Cellular and Molecular Life Sciences, 2013 - Springer
Intensive research in the last decade shows that the prototypic angiogenic factor vascular
endothelial growth factor (VEGF) can have direct effects in neurons and modulate processes …

Roles for VEGF in the adult

ASR Maharaj, PA D'Amore - Microvascular research, 2007 - Elsevier
The role of VEGF during development and in pathology is well known, but its function in
normal adult tissues is poorly understood. Adverse effects associated with the use of anti …

[HTML][HTML] Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells

M Ishikawa, Y Sawada, T Yoshitomi - Experimental eye research, 2015 - Elsevier
The interphotoreceptor matrix (IPM) is a highly organized structure with interconnected
domains surrounding cone and rod photoreceptor cells and extends throughout the …