Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

Mitotic spindle orientation is essential for cell fate decisions, epithelial maintenance, and
tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at …

The ability of cells to divide asymmetrically is essential for generating diverse cell types
during development. The past 10 years have seen tremendous progress in our …

The tight junction is an intracellular junctional structure that mediates adhesion between
epithelial cells and is required for epithelial cell function. Tight junctions control paracellular …

Elongation of the body axis is accompanied by the assembly of a polarized cytoarchitecture
that provides the basis for directional cell behavior. We find that planar polarity in the …

Cell division is commonly thought to involve the equal distribution of cellular components
into the two daughter cells. During many cell divisions, however, proteins, membrane …

Ten years ago, par-1 and par-3 were cloned as two of the six par genes essential for the
asymmetric division of the Caenorhabditis elegans zygote. PAR-1 is a protein kinase …

Cell polarity is defined as asymmetry in cell shape, protein distributions and cell functions. It
is characteristic of single-cell organisms, including yeast and bacteria, and cells in tissues of …

During convergent extension in Drosophila, polarized cell movements cause the germband
to narrow along the dorsal-ventral (DV) axis and more than double in length along the …

Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with
higher risk of kidney disease progression and cardiovascular events, but underlying …