To understand the placement of a certain protein in a physiological system and the
pathogenesis of related disorders, it is not only of interest to determine its function but also …

Objective: To give a comprehensive overview of the phenotypic and genetic spectrum of
STXBP1 encephalopathy (STXBP1-E) by systematically reviewing newly diagnosed and …

The blood vessel wall has a number of self‐healing properties, enabling it to minimize blood
loss and prevent or overcome infections in the event of vascular trauma. Endothelial cells …

Vascular endothelial cells produce and release compounds regulating vascular tone, blood
vessel growth and differentiation, plasma composition, coagulation and fibrinolysis, and also …

Plasma levels of the multimeric glycoprotein von Willebrand factor (VWF) constitute a
complex quantitative trait with a continuous distribution and wide range in the normal …

Blood vessels demonstrate a multitude of complex signaling programs that work in concert
to produce functional vasculature networks during development. A known, but less widely …

VWF biosynthesis, maturation, and secretion is a complex process, which mandates tight
regulation. Significant progress has been made in our understandings of VWF expression …

Abstract von Willebrand factor (VWF) is an essential hemostatic protein that is synthesized
and secreted by endothelial cells and stored in Weibel-Palade bodies (WPBs). The …

Weibel-Palade bodies (WPB) are unique secretory organelles of endothelial cells that store
factors regulating vascular hemostasis and local inflammation. Endothelial activation …

Abstract Weibel-Palade bodies (WPBs) are secretory granules that contain von Willebrand
factor and P-selectin, molecules that regulate hemostasis and inflammation, respectively …