Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

The complex bidirectional communication between the gut and the brain is finely
orchestrated by different systems, including the endocrine, immune, autonomic, and enteric …

Antibiotic-induced microbiome depletion (AIMD) has been used frequently to study the role
of the gut microbiome in pathological conditions. However, unlike germ-free mice, the effects …

Obesity is associated with metabolic alterations related to glucose homeostasis and
cardiovascular risk factors. These metabolic alterations are associated with low-grade …

The worldwide prevalence of metabolic diseases such as obesity, metabolic syndrome and
type 2 diabetes shows an upward trend in recent decades. A characteristic feature of these …

Exercise, obesity and type 2 diabetes are associated with elevated plasma concentrations of
interleukin-6 (IL-6). Glucagon-like peptide-1 (GLP-1) is a hormone that induces insulin …

Background Changes in gut microbiota composition and activity have been associated with
different metabolic disorders, including obesity, diabetes, and cardiometabolic disorders …

This review focuses on the mechanisms regulating the synthesis, secretion, biological
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic …

Despite substantial fluctuations in daily food intake, animals maintain a remarkably stable
body weight, because overall caloric ingestion and expenditure are exquisitely matched …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …