Objective Although the human small intestine serves primarily as an absorptive organ for
nutrients and water, it also has the ability to metabolise drugs. Interest in the small intestine …

The symptoms of chronic urticaria, be it chronic spontaneous urticaria (CSU) or chronic
inducible urticaria (CindU), are mediated primarily by the actions of histamine on H1 …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Several antihistamine drugs including terfenadine, ebastine, and astemizole have been
identified as substrates for CYP2J2. The overall importance of this enzyme in drug …

Urticaria affects all age groups of a population. It is triggered by allergens in foods, insect
bites, medications, and environmental conditions. Urticaria is characterized by itching, a …

Abstract Cytochrome P450 2J2 (CYP2J2) is an enzyme mainly found in human extrahepatic
tissues, with predominant expression in the cardiovascular systems and lower levels in the …

Cetirizine, marketed as a racemic mixture containing both levocetirizine and dextrocetirizine,
is a member of the second generation H1 antihistamines clinically used for the treatment of …

Cytochrome P450 (CYP) epoxygenases are a special subset of heme-containing CYP
enzymes capable of performing the epoxidation of polyunsaturated fatty acids (PUFA) and …

The main objective of this research work was the development and evaluation of
transfersomes integrated oral films for the bioavailability enhancement of Ebastine (EBT) to …

Abstract Cytochrome P4502J2 (CYP2J2) metabolizes arachidonic acid (AA) to
cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug …