Antimicrobial peptides: An alternative to traditional antibiotics

S Ji, F An, T Zhang, M Lou, J Guo, K Liu, Y Zhu… - European Journal of …, 2024 - Elsevier
As antibiotic-resistant bacteria and genes continue to emerge, the identification of effective
alternatives to traditional antibiotics has become a pressing issue. Antimicrobial peptides …

Antimicrobial peptides: Structure, mechanism, and modification

N Chen, C Jiang - European Journal of Medicinal Chemistry, 2023 - Elsevier
From the 1940s to the 1960s, the discovery of antibiotics held substantial promise for the
treatment of bacterial infection, and it was also widely used in food, agriculture, and other …

[HTML][HTML] Emerging trends and future opportunities for coumarin-heterocycle conjugates as antibacterial agents

YF Mustafa - Results in Chemistry, 2023 - Elsevier
Infectious diseases resulting from various strains of pathogenic bacteria are among the
leading causes of death and morbidity worldwide. The currently-available antibacterial …

Structure-activity relationship studies of thiazole agents with potential anti methicillin-resistance Staphylococcus aureus (MRSA) activity

J Wang, S Long, Z Liu, KP Rakesh, R Verma… - Process …, 2023 - Elsevier
Due to the increasing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to
conventional antibiotics, further efforts are needed to develop new antimicrobial agents …

Synthesis, Characterization, Bioactivity Screening and Computational Studies of Diphenyl− malonohydrazides and Pyridines Derivatives

MM Barqi, IM Abdellah, MR Eletmany, NM Ali… - …, 2023 - Wiley Online Library
A series of new hydrazide (3 a–j) and pyridine (11 a–j) derivatives were synthesized using a
convergent synthetic methodology by condensation of malono‐di (2‐phenylhydrazide) with …

1, 2, 3-Triazole-containing hybrids with potential antibacterial activity against ESKAPE pathogens

C Deng, H Yan, J Wang, K Liu, B Liu, Y Shi - European Journal of …, 2022 - Elsevier
ESKAPE pathogens, as priority 1 and 2 pathogens, are prevalent infectious agents
associated with high morbidity and mortality. ESKAPE can cause broad-spectrum diseases …

Development of membrane-targeting fluorescent 2-phenyl-1 h-phenanthro [9, 10-d] imidazole-antimicrobial peptide mimic conjugates against methicillin-resistant …

T Xu, X Yan, A Kang, L Yang, X Li, Y Tian… - Journal of Medicinal …, 2024 - ACS Publications
The escalation of multidrug-resistant bacterial infections, especially infections caused by
methicillin-resistant Staphylococcus aureus (MRSA), underscores the urgent need for novel …

Structure-activity relationship (SAR) and antibacterial activity of pyrrolidine based hybrids: A review

AA Bhat, N Tandon, I Singh, R Tandon - Journal of Molecular Structure, 2023 - Elsevier
Bacterial infections are a major health problem globally with a continuous increase in death
cases. The drug-resistance problem is associated with the available antibiotics making them …

Triazole derivatives as potential antifungal agents: A structure-activity relationship (SAR) studies

Y Hu, Z Liu, G Zha, S Long, MB Sridhara… - Process …, 2023 - Elsevier
Today's research is focused on developing new safe drugs of clinical importance. Nitrogen-
containing heterocycles are abundant in the common of therapeutic scaffolds. Triazoles are …

Fluorinated azoles as effective weapons in fight against methicillin-resistance staphylococcus aureus (MRSA) and its SAR studies

X Zhao, R Verma, MB Sridhara, KSS Kumar - Bioorganic Chemistry, 2024 - Elsevier
The rapid spread of Methicillin-resistant Staphylococcus aureus (MRSA) and its difficult-to-
treat skin and filmsy diseases are making MRSA a threat to human life. The most dangerous …