Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases

AG Wu, XG Zhou, G Qiao, LU Yu, Y Tang, LU Yan… - Ageing research …, 2021 - Elsevier
Neuroinflammation is considered as a detrimental factor in neurodegenerative diseases,
including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) …

Marine omega‐3 (n‐3) phospholipids: A comprehensive review of their properties, sources, bioavailability, and relation to brain health

MK Ahmmed, F Ahmmed, H Tian… - … reviews in food …, 2020 - Wiley Online Library
For several decades, there has been considerable interest in marine‐derived long chain n‐3
fatty acids (n‐3 LCPUFAs) due to their outstanding health benefits. n‐3 LCPUFAs can be …

Motor behavioral deficits in the cuprizone model: Validity of the rotarod test paradigm

C Lubrich, P Giesler, M Kipp - International journal of molecular sciences, 2022 - mdpi.com
Multiple Sclerosis (MS) is a neuroinflammatory disorder, which is histopathologically
characterized by multifocal inflammatory demyelinating lesions affecting both the central …

Remyelination in multiple sclerosis: findings in the cuprizone model

H Leo, M Kipp - International Journal of Molecular Sciences, 2022 - mdpi.com
Remyelination therapies, which are currently under development, have a great potential to
delay, prevent or even reverse disability in multiple sclerosis patients. Several models are …

Phytochemicals as novel therapeutic strategies for NLRP3 inflammasome-related neurological, metabolic, and inflammatory diseases

C Pellegrini, M Fornai, L Antonioli, C Blandizzi… - International journal of …, 2019 - mdpi.com
Several lines of evidence point out the relevance of nucleotide-binding oligomerization
domain leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome …

Behavioural phenotypes in the cuprizone model of central nervous system demyelination

MK Sen, DA Mahns, JR Coorssen… - … & Biobehavioral Reviews, 2019 - Elsevier
The feeding of cuprizone (CPZ) to animals has been extensively used to model the
processes of demyelination and remyelination, with many papers adopting a narrative linked …

Revealing the role of glycerophospholipid metabolism in asthma through plasma lipidomics

S Wang, K Tang, Y Lu, Z Tian, Z Huang, M Wang… - Clinica chimica acta, 2021 - Elsevier
Lipid mediators play an essential role in the pathogenesis of asthma. Many studies on the
differential expression of sphingolipids and fatty acid exist, but relatively few concerned …

Microglial NLRP3 inflammasome activation in multiple sclerosis

M Olcum, B Tastan, C Kiser, S Genc, K Genc - Advances in protein …, 2020 - Elsevier
Multiple sclerosis (MS) is a chronic, autoimmune and neuroinflammatory disease of the
central nervous system (CNS) mediated by autoreactive T cells directed against myelin …

Astrocytic neuroimmunological roles interacting with microglial cells in neurodegenerative diseases

M Gotoh, Y Miyamoto, H Ikeshima-Kataoka - International journal of …, 2023 - mdpi.com
Both astrocytic and microglial functions have been extensively investigated in healthy
subjects and neurodegenerative diseases. For astrocytes, not only various sub-types were …

Role of NLRP3 inflammasomes in neuroinflammation diseases

S Lin, X Mei - European neurology, 2021 - karger.com
Background: Inflammasomes are large intracellular multi-protein signaling complexes that
are formed in the cytosolic compartment as an inflammatory immune response to …