Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Obesity-induced chronic liver inflammation is a hallmark of nonalcoholic steatohepatitis
(NASH)—an aggressive form of nonalcoholic fatty liver disease. However, it remains unclear …

Candidate cis-regulatory elements (cCREs) in microglia demonstrate the most substantial
enrichment for Alzheimer's disease (AD) heritability compared to other brain cell types …

Triggering receptor expressed on myeloid cells 2 (TREM2) is strongly linked to Alzheimer's
disease (AD) risk, but its functions are not fully understood. Here, we found that TREM2 …

Alzheimer's disease, obesity-related metabolic syndrome, and cancer are the leading
causes of death and among the most costly medical conditions in the Western world. In all …

Background & Aims Previous single-cell RNA-sequencing analyses have shown that Trem2-
expressing macrophages are present in the liver during obesity, non-alcoholic …

Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …

Heart failure (HF) is a frequent consequence of myocardial infarction (MI). Identification of
the precise, time-dependent composition of inflammatory cells may provide clues for the …