The basal ganglia are a group of subcortical nuclei involved in a variety of processes
including motor, cognitive and mnemonic functions. One of their major roles is to integrate …

The gas NO is a messenger that modulates neuronal function. The use of NO donors and
NO synthase inhibitors as pharmacological tools revealed that this free radical is probably …

The past decade has seen a steady accumulation of evidence supporting a role for the
excitatory amino acid (EAA) neurotransmitter, glutamate, and its receptors in depression and …

A subpopulation of neurons in the globus pallidus projects to the neostriatum, which is the
major recipient of afferent information to the basal ganglia. Given the moderate nature of this …

Nitric oxide synthase (NOS), the enzyme that catalyzes the formation of nitric oxide from l-
arginine, exists in three major isoforms, neuronal, endothelial, and immunologic. Neuronal …

Enhancing cyclic nucleotides signaling by inhibition of phosphodiesterases (PDEs) is known
to be beneficial in disorders associated with cognitive decline. The present study was …

Microdialysis has become a frequently used method to study extracellular levels of GABA
and glutamate in the central nervous system. However, the fact that the major part of GABA …

Na+/Cl–-dependent neurotransmitter transporters, which constitute a gene superfamily, are
crucial for limiting neurotransmitter activity. Thus, it is critical to understand their regulation …

Nitric oxide (NO) is a multifunctional messenger in the CNS that can signal both in antero-
and retrograde directions across synapses. Many effects of NO are mediated through its …

An important role for the reactive gas nitric oxide (NO) in regulating striatal dopaminergic
neurotransmission was identified shortly after initial observations indicated that this …