Cellular senescence: from mechanisms to current biomarkers and senotherapies

V Lucas, C Cavadas, CA Aveleira - Pharmacological Reviews, 2023 - ASPET
An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

[HTML][HTML] Therapeutic plasticity of neural stem cells

L Ottoboni, B von Wunster, G Martino - Frontiers in neurology, 2020 - frontiersin.org
Neural stem cells (NSCs) have garnered significant scientific and commercial interest in the
last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes …

[HTML][HTML] Using multi-layer perceptron with Laplacian edge detector for bladder cancer diagnosis

I Lorencin, N Anđelić, J Španjol, Z Car - Artificial intelligence in medicine, 2020 - Elsevier
In this paper, the urinary bladder cancer diagnostic method which is based on Multi-Layer
Perceptron and Laplacian edge detector is presented. The aim of this paper is to investigate …

[HTML][HTML] Anti-senescent drug screening by deep learning-based morphology senescence scoring

D Kusumoto, T Seki, H Sawada, A Kunitomi… - Nature …, 2021 - nature.com
Advances in deep learning technology have enabled complex task solutions. The accuracy
of image classification tasks has improved owing to the establishment of convolutional …

Single-cell cytometry via multiplexed fluorescence prediction by label-free reflectance microscopy

S Cheng, S Fu, YM Kim, W Song, Y Li, Y Xue, J Yi… - Science …, 2021 - science.org
Traditional imaging cytometry uses fluorescence markers to identify specific structures but is
limited in throughput by the labeling process. We develop a label-free technique that …

[HTML][HTML] Prediction of cell migration potential on human breast cancer cells treated with Albizia lebbeck ethanolic extract using extreme machine learning

H Umar, MR Aliyu, AG Usman, UM Ghali, SI Abba… - Scientific Reports, 2023 - nature.com
Cancer is one of the major causes of death in the modern world, and the incidence varies
considerably based on race, ethnicity, and region. Novel cancer treatments, such as surgery …

[HTML][HTML] Cell morphology-based machine learning models for human cell state classification

Y Li, CM Nowak, U Pham, K Nguyen… - NPJ systems biology and …, 2021 - nature.com
Herein, we implement and access machine learning architectures to ascertain models that
differentiate healthy from apoptotic cells using exclusively forward (FSC) and side (SSC) …

[HTML][HTML] Application of image processing and transfer learning for the detection of rust disease

F Shahoveisi, H Taheri Gorji, S Shahabi… - Scientific Reports, 2023 - nature.com
Plant diseases introduce significant yield and quality losses to the food production industry,
worldwide. Early identification of an epidemic could lead to more effective management of …

[HTML][HTML] The role of convolutional neural networks in scanning probe microscopy: a review

I Azuri, I Rosenhek-Goldian… - Beilstein journal of …, 2021 - beilstein-journals.org
Progress in computing capabilities has enhanced science in many ways. In recent years,
various branches of machine learning have been the key facilitators in forging new paths …

[HTML][HTML] Prediction of mechanistic subtypes of Parkinson's using patient-derived stem cell models

K D'Sa, JR Evans, GS Virdi, G Vecchi, A Adam… - Nature Machine …, 2023 - nature.com
Parkinson's disease is a common, incurable neurodegenerative disorder that is clinically
heterogeneous: it is likely that different cellular mechanisms drive the pathology in different …