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Mannan-binding lectin (MBL)-associated serine proteases-1 and 2 (MASP-1 and MASP-2)
are homologous modular proteases that each interact with MBL, an oligomeric serum lectin …

A series of 2-amino-4 H-3, 1-benzoxazin-4-ones have been synthesized and evaluated as
inhibitors of the complement enzyme C1r. C1r is a serine protease at the beginning of the …

Proteases regulate numerous biological processes with a degree of specificity often dictated
by the amino acid sequence of the substrate cleavage site. To map protease/substrate …

Publisher Summary This chapter presents a survey on handles—both standard and
preformed, which have proved their usefulness over the years. The chapter emphasizes on …

The complement system plays a key role in innate immunity, inflammation, and coagulation.
The system is delicately balanced by negative regulatory mechanisms that modulate the …

A series of dipeptide derivatives of Rhodamine, each containing an arginine residue in the
P1 position and one of ten representative benzyloxycarbonyl (Cbz)-blocked amino acids in …

The subsite specificity of human lung and skin tryptase (trypsin-like enzyme) has been
studied at pH 7.5 using 17 amino acid and dipeptide thioester substrates and 14 tripeptide 4 …

Human C1-inhibitor (C1-Inh) forms an equimolar complex with complement proteinase C1s
that is resistant to dissociation by sodium dodecyl sulfate. The formation of this stable …

The specificity and reactivity of complement serine proteases D, B, Bb, C2, and C2a were
determined using a series of peptide thioester substrates. The rates of thioester hydrolysis …