In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …

Histone dacetylases (HDACs) are a group of enzymes that remove acetyl groups from
histones and regulate expression of tumor suppressor genes. They are implicated in many …

Abstract Histone deacetylase (EC 3.5. 1.98–HDAC) is an amidohydrolase involved in
deacetylating the histone lysine residues for chromatin remodeling and thus plays a vital …

Changes in chromatin structure and heritably regulating the gene expression by epigenetic
mechanisms, such as histone post-translational modification, are involved in most cellular …

In the pasture of oncology, anticancer agents having advanced modes of action are of great
interest because of increasing chronicity of resistance against anticancer drugs. Heterocyclic …

Heterocycles are being playing an important role in cancer treatment for years. Currently, a
number of anticancer agents are available on market, but concerns such as less …

Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing
histone deacetylation. Aberrant expression of HDACs is associated with various human …

Peptidyl fluoromethyl ketones occupy a pivotal role in the current scenario of synthetic
chemistry, thanks to their numerous applications as inhibitors of hydrolytic enzymes. The …

Histone deacetylases (HDACs) are critical epigenetic drug targets that have gained
significant attention in the scientific community for the treatment of cancer. The currently …

Drug repurposing aims to find novel indications of clinically used or experimental drugs.
Because drug data already exist, drug repurposing may save time and cost, and bypass …