Photoreceptor cell death and rescue in retinal detachment and degenerations

Y Murakami, S Notomi, T Hisatomi, T Nakazawa… - Progress in retinal and …, 2013 - Elsevier
Photoreceptor cell death is the ultimate cause of vision loss in various retinal disorders,
including retinal detachment (RD). Photoreceptor cell death has been thought to occur …

Cellular remodeling in mammalian retina: results from studies of experimental retinal detachment

SK Fisher, GP Lewis, KA Linberg… - Progress in retinal and eye …, 2005 - Elsevier
Retinal detachment, the separation of the neural retina from the retinal pigmented
epithelium, starts a cascade of events that results in cellular changes throughout the retina …

Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis

T Nakazawa, T Hisatomi, C Nakazawa… - Proceedings of the …, 2007 - National Acad Sciences
Photoreceptor apoptosis is a major cause of visual loss in retinal detachment (RD) and
several other visual disorders, but the underlying mechanisms remain elusive. Recently …

Photoreceptor apoptosis in human retinal detachment

JG Arroyo, L Yang, D Bula, DF Chen - American journal of ophthalmology, 2005 - Elsevier
PURPOSE: Although photoreceptor cell apoptosis has been demonstrated in various animal
models of retinal detachment (RD), little is known about its occurrence in human RD. We …

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore

LD Walensky, E Gavathiotis - Trends in biochemical sciences, 2011 - cell.com
BAX, the BCL-2-associated X protein, is a cardinal proapoptotic member of the BCL-2 family,
which regulates the critical balance between cellular life and death. Because so many …

Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin

T Nakazawa, M Takeda, GP Lewis… - … & visual science, 2007 - iovs.arvojournals.org
purpose. To characterize the reactions of retinal glial cells (astrocytes and Müller cells) to
retinal injury in mice that lack glial fibrillary acidic protein (GFAP) and vimentin (GFAP …

Too much death can kill you: inhibiting intrinsic apoptosis to treat disease

K Li, MF van Delft, G Dewson - The EMBO Journal, 2021 - embopress.org
Apoptotic cell death is implicated in both physiological and pathological processes. Since
many types of cancerous cells intrinsically evade apoptotic elimination, induction of …

Spectral-domain optical coherence tomography imaging of the detached macula in rhegmatogenous retinal detachment

H Nakanishi, M Hangai, N Unoki, A Sakamoto… - Retina, 2009 - journals.lww.com
Purpose: To assess detached macula in rhegmatogenous retinal detachment by using
spectral-domain optical coherence tomography. Methods: This retrospective study included …

[HTML][HTML] α-Aminoadipate induces progenitor cell properties of Muller glia in adult mice

M Takeda, A Takamiya, J Jiao, KS Cho… - … & visual science, 2008 - arvojournals.org
purpose. Retinal Müller glia in higher vertebrates have been reported to possess
progenitor cell properties and the ability to generate new neurons after injury. This study was …

Dynamic increase in extracellular ATP accelerates photoreceptor cell apoptosis via ligation of P2RX7 in subretinal hemorrhage

S Notomi, T Hisatomi, Y Murakami, H Terasaki… - PloS one, 2013 - journals.plos.org
Photoreceptor degeneration is the most critical cause of visual impairment in age-related
macular degeneration (AMD). In neovascular form of AMD, severe photoreceptor loss …