ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

There has been a resurgence of interest in the use of phenotypic screens in drug discovery
as an alternative to target-focused approaches. Given that oncology is currently the most …

Macroautophagy is an intracellular degradation system that utilizes the autophagosome to
deliver cytoplasmic components to the lysosome. Measuring autophagic activity is critically …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Defects in autophagy have been linked to a wide range of medical illnesses, including
cancer as well as infectious, neurodegenerative, inflammatory, and metabolic diseases …

A long-standing controversy is whether autophagy is a bona fide cause of mammalian cell
death. We used a cell-penetrating autophagy-inducing peptide, Tat-Beclin 1, derived from …

(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

Autophagy is a lysosome-dependent mechanism of intracellular degradation. The cellular
and molecular mechanisms underlying this process are highly complex and involve multiple …

Autophagy is an important intracellular catabolic mechanism that mediates the degradation
of cytoplasmic proteins and organelles. We report a potent small molecule inhibitor of …

Autophagy has been implicated in many physiological and pathological processes.
Accordingly, there is a growing scientific need to accurately identify, quantify, and …