In the early 1980s, while using purified glycosyltransferases to probe glycan structures on
surfaces of living cells in the murine immune system, we discovered a novel form of …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

O-GlcNAcylation is a post-translational modification of protein in response to genetic
variations or environmental factors, which is controlled by two highly conserved enzymes, ie …

Proteostasis is essential in the mammalian brain where post‐mitotic cells must function for
decades to maintain synaptic contacts and memory. The brain is dependent on glucose and …

Chronic, low‑grade inflammation associated with obesity and diabetes result from the
infiltration of adipose and vascular tissue by immune cells and contributes to cardiovascular …

Protein synthesis is essential for cell growth, proliferation, and survival. Protein synthesis is a
tightly regulated process that involves multiple mechanisms. Deregulation of protein …

Azido sugars have found frequent use as probes of biological systems in approaches
ranging from cell surface metabolic labeling to activity-based proteomic profiling of …

O-linked β-N-acetyl-glucosamine (O-GlcNAc) is an essential and ubiquitous post-
translational modification present in nucleic and cytoplasmic proteins of multicellular …

O-linked bN-acetyl-glucosaminylation (O-GlcNAcylation) is one of the most common post-
translational modifications of proteins, and is established by modifying the serine or …

Protein O-GlcNAcylation, involving the β-attachment of single N-acetylglucosamine (GlcNAc)
to the hydroxyl group of serine or threonine residues, is an O-linked glycosylation catalyzed …