Gut-liver axis: Pathophysiological concepts and clinical implications
H Tilg, TE Adolph, M Trauner - Cell metabolism, 2022 - cell.com
Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …
Inflammation in obesity, diabetes, and related disorders
Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …
Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …
Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome
How intestinal microbes regulate metabolic syndrome is incompletely understood. We show
that intestinal microbiota protects against development of obesity, metabolic syndrome, and …
that intestinal microbiota protects against development of obesity, metabolic syndrome, and …
[HTML][HTML] Global pandemics interconnected—obesity, impaired metabolic health and COVID-19
Obesity and impaired metabolic health are established risk factors for the non-
communicable diseases (NCDs) type 2 diabetes mellitus, cardiovascular disease …
communicable diseases (NCDs) type 2 diabetes mellitus, cardiovascular disease …
[HTML][HTML] Chronic inflammation and the hallmarks of aging
Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …
The gut-liver axis in liver disease: Pathophysiological basis for therapy
A Albillos, A De Gottardi, M Rescigno - Journal of hepatology, 2020 - Elsevier
The gut-liver axis refers to the bidirectional relationship between the gut and its microbiota,
and the liver, resulting from the integration of signals generated by dietary, genetic and …
and the liver, resulting from the integration of signals generated by dietary, genetic and …
The intestinal microbiota fuelling metabolic inflammation
Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …
[HTML][HTML] Negative effects of a high-fat diet on intestinal permeability: a review
MW Rohr, CA Narasimhulu, TA Rudeski-Rohr… - Advances in …, 2020 - Elsevier
The intestinal tract is the largest barrier between a person and the environment. In this role,
the intestinal tract is responsible not only for absorbing essential dietary nutrients, but also …
the intestinal tract is responsible not only for absorbing essential dietary nutrients, but also …
The gut–liver axis and the intersection with the microbiome
In the past decade, an exciting realization has been that diverse liver diseases—ranging
from nonalcoholic steatohepatitis, alcoholic steatohepatitis and cirrhosis to hepatocellular …
from nonalcoholic steatohepatitis, alcoholic steatohepatitis and cirrhosis to hepatocellular …