Tumor-activated carrier-free prodrug nanoparticles for targeted cancer Immunotherapy: Preclinical evidence for safe and effective drug delivery

MK Shim, S Yang, IC Sun, K Kim - Advanced Drug Delivery Reviews, 2022 - Elsevier
As immunogenic cell death (ICD) inducers initiating antitumor immune responses, certain
chemotherapeutic drugs have shown considerable potential to reverse the …

Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

Etching bulk covalent organic frameworks into nanoparticles of uniform and controllable size by the molecular exchange etching method for sonodynamic and immune …

D Wang, L Lin, T Li, M Meng, K Hao, Z Guo… - Advanced …, 2022 - Wiley Online Library
To improve the therapeutic effect of sonodynamic therapy (SDT), more effective and stable
sonosensitizers and therapeutic strategies are still required. A covalent organic framework …

[HTML][HTML] Anti-PD-L1 peptide-conjugated prodrug nanoparticles for targeted cancer immunotherapy combining PD-L1 blockade with immunogenic cell death

Y Moon, MK Shim, J Choi, S Yang, J Kim, WS Yun… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Cancer immunotherapy combining immune checkpoint blockade (ICB) with
chemotherapeutic drugs has provided significant clinical advances. However, such …

Design of Calixarene‐Based ICD Inducer for Efficient Cancer Immunotherapy

Z Zhang, YX Yue, Q Li, Y Wang, X Wu… - Advanced Functional …, 2023 - Wiley Online Library
Immunogenic cell death (ICD), which in situ generates cancer vaccines and elicits protective
cognate anticancer immunity, has brought brightness to cancer immunotherapy. However …

Emerging albumin-binding anticancer drugs for tumor-targeted drug delivery: current understandings and clinical translation

H Cho, SI Jeon, CH Ahn, MK Shim, K Kim - Pharmaceutics, 2022 - mdpi.com
Albumin has shown remarkable promise as a natural drug carrier by improving
pharmacokinetic (PK) profiles of anticancer drugs for tumor-targeted delivery. The …

Polymeric nanoparticle-based nanovaccines for cancer immunotherapy

Y Zhang, J Chen, L Shi, F Ma - Materials Horizons, 2023 - pubs.rsc.org
Therapeutic cancer vaccines, which are designed to amplify tumor-specific T cell responses,
have been envisioned as one of the most powerful tools for effective cancer immunotherapy …

Light-triggered photodynamic nanomedicines for overcoming localized therapeutic efficacy in cancer treatment

J Choi, IC Sun, HS Hwang, HY Yoon, K Kim - Advanced Drug Delivery …, 2022 - Elsevier
Photodynamic nanomedicines have significantly enhanced the therapeutic efficacy of
photosensitizers (PSs) by overcoming critical limitations of PSs such as poor water solubility …

A Versatile Nanoplatform Based on Metal‐Phenolic Networks Inhibiting Tumor Growth and Metastasis by Combined Starvation/Chemodynamic/Immunotherapy

Z Fu, Y Zhang, X Chen, N Wang, R Ma… - Advanced Functional …, 2023 - Wiley Online Library
Although much progress has been made by multifunctional nanoplatforms in the treatment of
cancer, several defects of existing nanoplatforms, such as tedious preparation, poor …

Cu-Chelated polydopamine nanoparticles as a photothermal medium and “immunogenic cell death” inducer for combined tumor therapy

N Xu, A Hu, X Pu, J Wang, X Liao, Z Huang… - Journal of Materials …, 2022 - pubs.rsc.org
Chemodynamic therapy (CDT) and photothermal therapy (PTT) have been powerful
technologies for tumor ablation. However, how to realize efficient CDT and PTT synergetic …