The ability to design functional sequences and predict effects of variation is central to protein
engineering and biotherapeutics. State-of-art computational methods rely on models that …

An Ab molecule or a BCR that is able to bind multiple structurally unrelated Ags is defined as
polyreactive. Polyreactive Abs and BCRs constitute an important part of immune repertoires …

Atopic dermatitis (AD) is a common skin disease affecting 20% of the population beginning
usually before one year of age. It is associated with the emergence of allergen-specific IgE …

A major biomedical challenge is the interpretation of genetic variation and the ability to
design functional novel sequences. Since the space of all possible genetic variation is …

The relative orientation of the two variable domains, VH and VL, influences the shape of the
antigen binding site, that is, the paratope, and is essential to understand antigen specificity …

Intravenous and subcutaneous immunoglobulin preparations, consisting of IgG class
antibodies, are increasingly used to treat a broad range of pathological conditions, including …

Molecular mimicry is fundamental to biology and transcends to many disciplines ranging
from immune pathology to drug design. Structural characterization of molecular partners has …

Granulocytes are key effector cells of the innate immune system that cause substantial by-
stander tissue damage in a broad range of inflammatory disorders. Specific antibodies with …

Conformational flexibility in antibody-combining sites has been hypothesized to facilitate
polyspecificity toward multiple unique epitopes and enable the limited germline repertoire to …

Large-scale profiling and monitoring of antibody repertoires is possible through next
generation sequencing (NGS), phage display libraries and microarrays. These methods can …