[HTML][HTML] Emerging role of ferroptosis in diabetic kidney disease: molecular mechanisms and therapeutic opportunities

H Wang, D Liu, B Zheng, Y Yang, Y Qiao… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Diabetic kidney disease (DKD) is one of the most common and severe microvascular
complications of diabetes mellitus (DM), and has become the leading cause of end-stage …

Targeting ferroptosis: a new therapeutic opportunity for kidney diseases

Z Long, Y Luo, M Yu, X Wang, L Zeng… - Frontiers in …, 2024 - frontiersin.org
Ferroptosis is a form of non-apoptotic regulated cell death (RCD) that depends on iron and
is characterized by the accumulation of lipid peroxides to lethal levels. Ferroptosis involves …

VDR activation attenuates renal tubular epithelial cell ferroptosis by regulating Nrf2/HO‐1 signaling pathway in diabetic nephropathy

H Wang, X Yu, D Liu, Y Qiao, J Huo, S Pan… - Advanced …, 2024 - Wiley Online Library
Diabetic nephropathy (DN) is a serious microvascular complication of diabetes. Ferroptosis,
a new form of cell death, plays a crucial role in the pathogenesis of DN. Renal tubular injury …

Identification and experimental validation of ferroptosis-related gene lactotransferrin in age-related hearing loss

C Zeng, X Gu, Y Chen, Y Lin, J Chen… - Frontiers in Aging …, 2024 - frontiersin.org
Objective To reveal the relationship between ARHL and ferroptosis and screen ferroptosis-
related genes (FRGs) in ARHL. Methods Bioinformatics were used to analyze the hub genes …

Identification of ferroptosis-related genes and pathways in diabetic kidney disease using bioinformatics analysis

D Liu, W Zhou, L Mao, Z Cui, S Jin - Scientific Reports, 2022 - nature.com
Diabetic kidney disease (DKD) is a major public health issue because of its refractory
nature. Ferroptosis is a newly coined programmed cell death characterized by the …

Single-Cell Sequencing Reveals the Expression of Immune-Related Genes in Macrophages of Diabetic Kidney Disease

X Shao, Y Shi, Y Wang, L Zhang, P Bai, JM Wang… - Inflammation, 2024 - Springer
Diabetic kidney disease (DKD) is characterized by macrophage infiltration, which requires
further investigation. This study aims to identify immune-related genes (IRGs) in …

Graph theory-based simulation tools for protein structure networks

KF Kantelis, V Asteriou… - … Modelling Practice and …, 2022 - Elsevier
Abstract Analysis of interactions in biological systems is at the core of almost every
biological study. Being a principal tool, graph theory as a mathematical formalism, aims to …

Identification of genes reveals the mechanism of cell ferroptosis in diabetic nephropathy

X Wang, L Jiang, XQ Liu, YB Huang, W Zhu… - Frontiers in …, 2022 - frontiersin.org
Aims/Introduction: Diabetic nephropathy (DN) is one of the main complications of diabetes.
Genomics may reveal the essential pathogenesis of DN. We analyzed datasets to search for …

Ferroptosis: new insight into the mechanisms of diabetic nephropathy and retinopathy

L Li, Y Dai, D Ke, J Liu, P Chen, D Wei… - Frontiers in …, 2023 - frontiersin.org
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are the most serious and common
diabetes-associated complications. DN and DR are all highly prevalent and dangerous …

Integrative analyses of biomarkers and pathways for diabetic nephropathy

B Li, X Zhao, W Xie, Z Hong, Y Zhang - Frontiers in Genetics, 2023 - frontiersin.org
Background: Diabetic nephropathy (DN) is a widespread diabetic complication and a major
cause of terminal kidney disease. There is no doubt that DN is a chronic disease that …