Vanadium is a transition metal that, being ubiquitously distributed in soil, crude oil, water
and air, also found roles in biological systems and is an essential element in most living …

A little over one hundred years ago, a vanadium-containing compound was assessed
clinically for use in treatment of human diabetic patients. The results were somewhat …

Vanadium, element number 23, atomic weight 50.94, is normally present at very low
concentrations (< 10-8 M) in virtually all cells in plants and animals. Vanadium in oxidation …

We examined the in vivo metabolic effects of vanadyl sulfate (VS) in non-insulin-dependent
diabetes mellitus (NIDDM). Six NIDDM subjects treated with diet and/or sulfonylureas were …

Compounds of the trace element vanadium exert various insulin‐like effects in in vitro and in
vivo systems. These include their ability to improve glucose homeostasis and insulin …

Oxidative stress is defined as excessive production of reactive oxygen species (ROS) in the
presence of diminished antioxidant substances. It has been shown that oxidative stress has …

The safety and efficacy of vanadyl sulfate (VS) was tested in a single-blind, placebo-
controlled study. Eight patients (four men and four women) with non—insulin-dependent …

We demonstrated in 1985 that vanadium administered in the drinking water to streptozotocin
(STZ) diabetic rats restored elevated blood glucose to normal. Subsequent studies have …

Vanadyl sulfate (VOSO4) is an oxidative form of vanadium that in vitro and in animal models
of diabetes has been shown to reduce hyperglycemia and insulin resistance. Small clinical …

Vanadium compounds can mimic actions of insulin through alternative signalling pathways.
The effects of three organic vanadium compounds were studied in non‐ketotic …