The secretome of filarial nematodes and its role in host-parasite interactions and pathogenicity in onchocerciasis-associated epilepsy
A Hotterbeekx, J Perneel, MK Vieri… - Frontiers in Cellular …, 2021 - frontiersin.org
Filarial nematodes secrete bioactive molecules which are of interest as potential mediators
for manipulating host biology, as they are readily available at the host-parasite interface. The …
for manipulating host biology, as they are readily available at the host-parasite interface. The …
Functional diversity of the excretory/secretory proteins of nematode parasites
P Joshi, PKK Mishra - Acta Parasitologica, 2022 - Springer
Introduction Parasites release a wide array of protein as excretory and secretory products
(ESPs). Irrespective of their mode of propagation, ESPs are found to be secreted or excreted …
(ESPs). Irrespective of their mode of propagation, ESPs are found to be secreted or excreted …
Inhibition of cathepsin B by E-64 induces oxidative stress and apoptosis in filarial parasite
M Wadhawan, N Singh, S Rathaur - PLoS One, 2014 - journals.plos.org
Background Current available antifilarial drug strategies only eliminate the larval stages of
filarial parasites. Therefore, there is an urgent need of drugs which are macrofilaricidals …
filarial parasites. Therefore, there is an urgent need of drugs which are macrofilaricidals …
Combination of DEC plus aspirin induced mitochondrial mediated apoptosis in filarial parasite Setaria cervi
A Singh, S Rathaur - Biochimie, 2010 - Elsevier
Diethylcarbamazine (DEC) is the main drug used against lymphatic filariasis but it is only
microfilaricidal. Hence there is an urgent need for adulticidal drug. Aspirin is known …
microfilaricidal. Hence there is an urgent need for adulticidal drug. Aspirin is known …
Presence of ecto-protein tyrosine phosphatase activity is vital for survival of Setaria cervi, a bovine filarial parasite
N Singh, P Heneberg, S Rathaur - Parasitology research, 2014 - Springer
The ecto protein tyrosine phosphatases (PTP) are known to play a crucial role in the
pathogenesis and survival of the intracellular parasites. However, their presence and role in …
pathogenesis and survival of the intracellular parasites. However, their presence and role in …