Diastolic dysfunction, a prevalent condition characterized by impaired relaxation and filling
of the left ventricle, significantly contributes to heart failure with preserved ejection fraction …

The mechanism underlying ischaemic heart disease (IHD) has been primarily attributed to
obstructive coronary artery disease (CAD). However, non-obstructive coronary arteries are …

Capillary pericytes are important regulators of cerebral blood flow, blood–brain barrier
integrity and neuroinflammation, but can become lost or dysfunctional in disease. The …

The adult mammalian heart contains a large population of pericytes that play important roles
in homeostasis and disease. In the normal heart, pericytes regulate microvascular …

Endothelial dysfunction is considered a key element in the early pathogenesis of
neurodegenerative disorders. Dysfunction of the cerebral endothelial cells can result in …

The pericyte coverage of microvessels is altered in metabolic diseases, but the mechanisms
regulating pericyte–endothelial cell communication remain unclear. This study investigated …

Coronary microvascular disease (CMD) and impaired coronary blood flow control are
defects that occur early in the pathogenesis of heart failure in cardiometabolic conditions …