Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes
One of the first biological machineries to be created seems to have been the ribosome.
Since then, organisms have dedicated great efforts to optimize this apparatus. The …
Since then, organisms have dedicated great efforts to optimize this apparatus. The …
Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases
The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
An iron–sulfur cluster in the zinc-binding domain of the SARS-CoV-2 helicase modulates its RNA-binding and-unwinding activities
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, uses an RNA-dependent RNA polymerase along with several accessory factors …
COVID-19, uses an RNA-dependent RNA polymerase along with several accessory factors …
Iron–sulfur clusters as inhibitors and catalysts of viral replication
K Honarmand Ebrahimi, S Ciofi-Baffoni… - Nature Chemistry, 2022 - nature.com
A virus hijacks host cellular machineries and metabolites in order to reproduce. In response,
the innate immune system activates different processes to fight back. Although many aspects …
the innate immune system activates different processes to fight back. Although many aspects …
RNA polymerase III subunit mutations in genetic diseases
E Lata, K Choquet, F Sagliocco, B Brais… - Frontiers in Molecular …, 2021 - frontiersin.org
RNA polymerase (Pol) III transcribes small untranslated RNAs such as 5S ribosomal RNA,
transfer RNAs, and U6 small nuclear RNA. Because of the functions of these RNAs, Pol III …
transfer RNAs, and U6 small nuclear RNA. Because of the functions of these RNAs, Pol III …
CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
During translation of the genomic RNA of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the causative virus in the COVID-19 pandemic, host ribosomes undergo …
(SARS-CoV-2), the causative virus in the COVID-19 pandemic, host ribosomes undergo …
Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets
N Maio, BAP Lafont, D Sil, Y Li, JM Bollinger Jr… - Science, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of COVID-
19, uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and …
19, uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and …
RNA polymerases I and III in development and disease
KEN Watt, J Macintosh, G Bernard… - Seminars in cell & …, 2023 - Elsevier
Ribosomes are macromolecular machines that are globally required for the translation of all
proteins in all cells. Ribosome biogenesis, which is essential for cell growth, proliferation …
proteins in all cells. Ribosome biogenesis, which is essential for cell growth, proliferation …
[HTML][HTML] Unusual structures and unknown roles of FeS clusters in metalloenzymes seen from a resonance Raman spectroscopic perspective
G Caserta, L Zuccarello, C Barbosa, CM Silveira… - Coordination Chemistry …, 2022 - Elsevier
The universe of known biological FeS clusters is constantly enlarging. Besides the
conventional, well described [2Fe–2S],[3Fe–4S] and cubane [4Fe–4S] clusters, novel …
conventional, well described [2Fe–2S],[3Fe–4S] and cubane [4Fe–4S] clusters, novel …
The nuclear and cytoplasmic activities of RNA polymerase III, and an evolving transcriptome for surveillance
AC Kessler, RJ Maraia - Nucleic Acids Research, 2021 - academic.oup.com
A 1969 report that described biochemical and activity properties of the three eukaryotic RNA
polymerases revealed Pol III as highly distinguishable, even before its transcripts were …
polymerases revealed Pol III as highly distinguishable, even before its transcripts were …