Abstract Three-dimensional (3D) stem cell culture systems have attracted considerable
attention as a way to better mimic the complex interactions between individual cells and the …

Organoids, miniature and simplified in vitro model systems that mimic the structure and
function of organs, have attracted considerable interest due to their promising applications in …

The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution
to the field of regenerative medicine, paving way for identifying the true potential of human …

The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

The regenerative function of liver can be destroyed by viral infection, drug poisoning and
tumorigenesis, resulting in irreversible damage. Numerous approaches in promoting liver …

Drug-induced hepatotoxicity is a leading cause of drug withdrawal from the market. High-
throughput screening utilizing in vitro liver models is critical for early-stage liver toxicity …

Liver cancer and disease are among the most socially challenging global health concerns.
Although organ transplantation, surgical resection and anticancer drugs are the main …

Cell culture is one of the most core and fundamental techniques employed in the fields of
biology and medicine. At present, although the two‐dimensional cell culture method is …

The call for a paradigm change in toxicology from the United States National Research
Council in 2007 initiates awareness for the invention and use of human‐relevant alternative …

Liver organoids represent emerging human-relevant in vitro liver models that have a wide
range of biomedical applications in basic medical studies and preclinical drug discovery …