ABSTRACT p27Kip1 was first discovered as a key regulator of cell proliferation. The
canonical function of p27Kip1 is inhibition of cyclin-dependent kinase (CDK) activity. In …

Mitosis is the process of cell division and is regulated by checkpoints in the cell cycle. G1-S,
S, and G2-M are the three main checkpoints that prevent initiation of the next phase of the …

Abstract miR-223 is an anti-inflammatory miRNA that in cancer acts either as an
oncosuppressor or oncopromoter, in a context-dependent manner. In breast cancer, we …

Epithelial ovarian cancer (EOC) is an infrequent but highly lethal disease, almost invariably
treated with platinum‐based therapies. Improving the response to platinum represents a …

Abstract Knowledge of the molecular mechanisms on malignant tumors is very critical for the
development of new treatment strategies like molecularly targeted therapies. In last 5 years …

Abstract p27 Kip1 is a cell cycle regulator firstly identified as a cyclin-dependent kinase
inhibitor. For a long time, its function has been associated to cell cycle progression inhibition …

Even in the face of damaging insults, most cells maintain stability over time through multiple
homeostatic pathways, including maintenance of the microtubule cytoskeleton that is …

Standard of care for Epithelial Ovarian Cancer (EOC) patients relies on platinum-based
therapy. However, acquired resistance to platinum occurs frequently and predicts poor …

ABSTRACT p27 plays critical roles in cell proliferation, differentiation, and apoptosis, which
have been well studied in mammals and Drosophila. However, the mechanisms underlying …

The cyclin-dependent kinase (CDK) inhibitor p27kip1 is a critical regulator of the G1/S-
phase transition of the cell cycle and also regulates microtubule (MT) stability. This latter …