Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor
for end-stage liver diseases with no available therapies. Dysregulated immune responses …

Cirrhosis is a multisystemic disease wherein inflammatory responses originating from
advanced liver disease and its sequelae affect distant compartments. Patients with cirrhosis …

Tissue injury and inflammatory response trigger the development of fibrosis in various
diseases. It has been recognized that both innate and adaptive immune cells are important …

The liver is a lymphoid organ with unique immunological properties, particularly, its
predominant innate immune system. The balance between immune tolerance and immune …

Hepatic fibrosis is a dynamic process that occurs as a wound healing response against liver
injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells …

Tissue-resident immune cells reside in distinct niches across organs, where they contribute
to tissue homeostasis and rapidly respond to perturbations in the local microenvironment …

Cancer is a complex disease, and despite incredible progress over the last decade, it
remains the leading cause of death worldwide. Liver cancers, including hepatocellular …

The liver is a central immunomodulator that ensures a homeostatic balance between
protection and immunotolerance. A hallmark of hepatocellular carcinoma (HCC) is the …

Intestinal diseases have always posed a serious threat to human health, with inflammatory
bowel disease (IBD) being one of them. IBD is an autoimmune disease characterized by …

Background Type 2 innate lymphoid cells (ILC2s) are relevant players in type 2 asthma.
They initiate eosinophil infiltration and airway hyperreactivity (AHR) through cytokine …