Breast cancer remains a leading cause of cancer-related mortality in women, reflecting
profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last …

Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …

Chromosomal instability (CIN) is a driver of cancer metastasis,,–, yet the extent to which this
effect depends on the immune system remains unknown. Using ContactTracing—a newly …

Cytokines are critical in regulating immune responses and cellular behavior, playing dual
roles in both normal physiology and the pathology of diseases such as cancer. These …

Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …

Metastasis frequently develops from disseminated cancer cells that remain dormant after the
apparently successful treatment of a primary tumour. These cells fluctuate between an …

Over the past decade, it has become clear that the stimulator of interferon genes (STING)
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …

Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural
and numerical chromosomal abnormalities during cell division, which contributes to tumour …

Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …

Historically, cancer research and therapy have focused on malignant cells and their tumor
microenvironment. However, the vascular, lymphatic and nervous systems establish long …