Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Calixarenes (CAs), representing the third generation of supramolecular hosts and one of the
most widely studied macrocyclic scaffolds, offer (almost) unlimited structure and application …

Carboplatin (CRBP) is a chemotherapeutic agent based on platinum that has applications in
the effective management of ovarian, testis, cervical, neck, head, and small cell lung cancer …

Since cancer is a multifactorial disease with a high mortality rate, the study of new
therapeutic strategies is one of the main objectives in modern research. Numerous …

Paclitaxel (PTX) is an effective anticancer chemical with a broad spectrum that was primarily
obtained from a curative shrub, specifically the bark of Taxus brevifolia tree. It belongs to a …

Macrocyclic amphiphiles as an emerging family of artificial amphiphiles have gained
considerable attention in recent years on account of their fascinating recognition and …

Simple Summary Regulation of gene expression is important for appropriate cell
development but can also lead to inappropriate cell transformation resulting in cancer …

Amphiphilic macrocycles, such as p-sulfonatocalix [6] arenes (p-SC6), have demonstrated
great potential in designing synthetic nanovesicles based on self-assembly approaches …

Nanoparticle-based drug delivery system offers a promising platform for combination cancer
therapy. However, the inefficient drug release in cells reduces the therapeutic efficacy of …

Purpose Cervical cancer is one of the most common causes of death among women
globally. Combinations of cisplatin, paclitaxel, bevacizumab, carboplatin, topotecan, and …