SARS-CoV-2 accessory proteins in viral pathogenesis: knowns and unknowns

N Redondo, S Zaldívar-López, JJ Garrido… - Frontiers in …, 2021 - frontiersin.org
There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in
COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles …

Targeting the NLRP3 inflammasome in severe COVID-19

TL Freeman, TH Swartz - Frontiers in immunology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

Evolutionary trajectory of SARS-CoV-2 and emerging variants

J Singh, P Pandit, AG McArthur, A Banerjee… - Virology journal, 2021 - Springer
The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 …

Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases

S Kakavandi, I Zare, M VaezJalali, M Dadashi… - Cell Communication and …, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by a new member of the
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …

Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research

F Hufsky, K Lamkiewicz, A Almeida… - Briefings in …, 2021 - academic.oup.com
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of
the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of …

Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants

M Moriyama, C Lucas, VS Monteiro… - Proceedings of the …, 2023 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs)
possess mutations that confer resistance to neutralizing antibodies within the Spike protein …

Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2

L Zinzula - Biochemical and biophysical research communications, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains nine
open reading frames (ORFs) that encode for accessory proteins which, although …

Unique mutations in SARS-CoV-2 Omicron subvariants' non-spike proteins: Potential impacts on viral pathogenesis and host immune evasion

A Hossain, S Akter, AA Rashid, S Khair… - Microbial …, 2022 - Elsevier
SARS-CoV-2 is the causative agent behind the ongoing COVID-19 pandemic. This virus is a
cumulative outcome of mutations, leading to frequent emergence of new variants and their …

Two-step fitness selection for intra-host variations in SARS-CoV-2

J Li, P Du, L Yang, J Zhang, C Song, D Chen, Y Song… - Cell reports, 2022 - cell.com
Spontaneous mutations introduce uncertainty into coronavirus disease 2019 (COVID-19)
control procedures and vaccine development. Here, we perform a spatiotemporal analysis …