TH2 cell development and function
JA Walker, ANJ McKenzie - Nature Reviews Immunology, 2018 - nature.com
Abstract T helper 2 (TH 2) cells orchestrate protective type 2 immune responses, such as
those that target helminths and facilitate tissue repair, but also contribute to chronic …
those that target helminths and facilitate tissue repair, but also contribute to chronic …
Computational flow cytometry: helping to make sense of high-dimensional immunology data
Recent advances in flow cytometry allow scientists to measure an increasing number of
parameters per cell, generating huge and high-dimensional datasets. To analyse, visualize …
parameters per cell, generating huge and high-dimensional datasets. To analyse, visualize …
[HTML][HTML] Single-cell mapping of human brain cancer reveals tumor-specific instruction of tissue-invading leukocytes
E Friebel, K Kapolou, S Unger, NG Núñez, S Utz… - Cell, 2020 - cell.com
Brain malignancies can either originate from within the CNS (gliomas) or invade from other
locations in the body (metastases). A highly immunosuppressive tumor microenvironment …
locations in the body (metastases). A highly immunosuppressive tumor microenvironment …
[HTML][HTML] A subset of Kupffer cells regulates metabolism through the expression of CD36
C Blériot, E Barreby, G Dunsmore, R Ballaire… - Immunity, 2021 - cell.com
Tissue macrophages are immune cells whose phenotypes and functions are dictated by
origin and niches. However, tissues are complex environments, and macrophage …
origin and niches. However, tissues are complex environments, and macrophage …
Fast interpolation-based t-SNE for improved visualization of single-cell RNA-seq data
Abstract t-distributed stochastic neighbor embedding (t-SNE) is widely used for visualizing
single-cell RNA-sequencing (scRNA-seq) data, but it scales poorly to large datasets. We …
single-cell RNA-sequencing (scRNA-seq) data, but it scales poorly to large datasets. We …
High-dimensional single-cell mapping of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease
D Mrdjen, A Pavlovic, FJ Hartmann, B Schreiner… - Immunity, 2018 - cell.com
Individual reports suggest that the central nervous system (CNS) contains multiple immune
cell types with diverse roles in tissue homeostasis, immune defense, and neurological …
cell types with diverse roles in tissue homeostasis, immune defense, and neurological …
[HTML][HTML] Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts
Memory CD8+ T cells can be broadly divided into circulating (T CIRCM) and tissue-resident
memory T (T RM) populations. Despite well-defined migratory and transcriptional …
memory T (T RM) populations. Despite well-defined migratory and transcriptional …
Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species
Dendritic cells (DCs) are professional antigen-presenting cells that hold great therapeutic
potential. Multiple DC subsets have been described, and it remains challenging to align …
potential. Multiple DC subsets have been described, and it remains challenging to align …
Exploring genetic interaction manifolds constructed from rich single-cell phenotypes
How cellular and organismal complexity emerges from combinatorial expression of genes is
a central question in biology. High-content phenotyping approaches such as Perturb-seq …
a central question in biology. High-content phenotyping approaches such as Perturb-seq …
CAR T cells for infection, autoimmunity and allotransplantation
Chimeric antigen receptors (CARs) have shown remarkable ability to re-direct T cells to
target CD19-expressing tumours, resulting in remission rates of up to 90% in individuals with …
target CD19-expressing tumours, resulting in remission rates of up to 90% in individuals with …