Angiotensin II and dengue

JA Mosquera-Sulbaran, A Pedreañez… - Archives of …, 2023 - Springer
Dengue is a disease caused by a flavivirus that is transmitted principally by the bite of an
Aedes aegypti mosquito and represents a major public-health problem. Many studies have …

Cardiovascular toxicity in antitumor therapy: biological and therapeutic insights

X Lin, X Ma, S Zhao, J Yao, L Han, Y Jing, X Xue - Trends in Cancer, 2024 - cell.com
The evolution of antitumor therapies has significantly improved cancer prognosis but has
concurrently resulted in cardiovascular toxicities. Understanding the biological mechanisms …

Formulation development, optimization by box-behnken design, and in vitro characterization of gefitinib phospholipid complex based nanoemulsion drug delivery …

Mohit, P Kumar, P Solanki, B Mangla… - Journal of Pharmaceutical …, 2023 - Springer
Purpose Gefitinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor
that has been authorized for the treatment of non-small lung cancer; however, its …

Role of Gut Microbiota in Dengue

A Pedreañez, Y Carrero, R Vargas… - Reviews in Medical …, 2024 - Wiley Online Library
Dengue is a disease caused by a flavivirus (DENV) and transmitted by the bite of a
mosquito, primarily the Aedes aegypti and Aedes albopictus species. Previous studies have …

Mechanism Underlying Triple VEGFR Inhibitor Tivozanib-Induced Hypertension in Mice Model

WA Alanazi, AS Alanazi, DM El-Nagar, AM Aljuraybah… - Pharmaceuticals, 2023 - mdpi.com
Tivozanib is a triple vascular endothelial growth factor receptor inhibitor, recently approved
for the treatment of refractory advanced renal cell carcinoma. Clinical studies showed that …

Ellagic acid protects against angiotensin II‐induced hypertrophic responses through ROS‐mediated MAPK pathway in H9c2 cells

YC Lee, YC Jou, WC Chou, KL Tsai… - Environmental …, 2024 - Wiley Online Library
The early myocardial response of hypertension is an elevation of angiotensin‐II (Ang‐II)
concentration, leading to heart failure and cardiac hypertrophy. This hypertrophic event of …

Chromatographic analysis of ponatinib and its impurities: method development, validation, and identification of new degradation product

J Wang, Y Zhu, J Qin, W Wu, R Huang, L Cai - Frontiers in Chemistry, 2024 - frontiersin.org
Background Ponatinib, a third-generation tyrosine kinase inhibitor, is employed in the
management of adult chronic myeloid leukemia. Nevertheless, the presence of process …

Clinical Relevance and Mechanistic Underpinnings of Tyrosine Kinase Inhibitor Associated Cardiotoxicities

S Torelli, V Agnihotri, H Zhu, Z Wang, P Cheng… - … Treatment Options in …, 2025 - Springer
Here, we provide a review of the most clinically relevant cardiovascular toxicities to raise
awareness when caring for patients on these drugs. TKIs exemplify the complexity in …

[HTML][HTML] Valsartan prevents gefitinib-induced lung inflammation, oxidative stress, and alteration of plasma metabolites in rats

WA Alanazi, HN Alhamami, AA Alshamrani… - Saudi Journal of …, 2023 - Elsevier
Gefitinib (GEF) is an inhibitor of the epidermal growth factor receptor, linked to higher risk of
severe/fatal interstitial lung disease (ILD). This study was performed to determine the …

Protective effect of valsartan alone and in combination with neprilysin inhibitor (valsartan+ sacubitril) against hepatic ischemia–reperfusion injury: targeting …

DE Elsayed Abouzed, DA Bafail, SM Refaie… - Naunyn-Schmiedeberg's …, 2025 - Springer
Ischemia–reperfusion injury (IRI) is a common pathogenic situation that arises throughout all
liver surgeries, including liver transplants. We aimed to compare the preventive effects of …