[HTML][HTML] Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species
A Daiber - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2010 - Elsevier
This review highlights the important role of redox signaling between mitochondria and
NADPH oxidases. Besides the definition and general importance of redox signaling, the …
NADPH oxidases. Besides the definition and general importance of redox signaling, the …
Regulation of nitric oxide-sensitive guanylyl cyclase
A Friebe, D Koesling - Circulation research, 2003 - Am Heart Assoc
In this review, we outline the current knowledge on the regulation of nitric oxide (NO)-
sensitive guanylyl cyclase (GC). Besides NO, the physiological activator that binds to the …
sensitive guanylyl cyclase (GC). Besides NO, the physiological activator that binds to the …
Effects of angiotensin II infusion on the expression and function of NAD (P) H oxidase and components of nitric oxide/cGMP signaling
H Mollnau, M Wendt, K Szöcs, B Lassègue… - Circulation …, 2002 - Am Heart Assoc
Angiotensin II infusion causes endothelial dysfunction by increasing NAD (P) H oxidase-
mediated vascular superoxide production. However, it remains to be elucidated how in vivo …
mediated vascular superoxide production. However, it remains to be elucidated how in vivo …
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
JP Stasch, PM Schmidt, PI Nedvetsky… - The Journal of …, 2006 - Am Soc Clin Investig
ROS are a risk factor of several cardiovascular disorders and interfere with NO/soluble
guanylyl cyclase/cyclic GMP (NO/sGC/cGMP) signaling through scavenging of NO and …
guanylyl cyclase/cyclic GMP (NO/sGC/cGMP) signaling through scavenging of NO and …
Vascular consequences of endothelial nitric oxide synthase uncoupling for the activity and expression of the soluble guanylyl cyclase and the cGMP-dependent …
Endothelial dysfunction in the setting of cardiovascular risk factors, such as
hypercholesterolemia, hypertension, diabetes mellitus, chronic smoking, as well as in the …
hypercholesterolemia, hypertension, diabetes mellitus, chronic smoking, as well as in the …
Explaining the phenomenon of nitrate tolerance
During the last century, nitroglycerin has been the most commonly used antiischemic and
antianginal agent. Unfortunately, after continuous application, its therapeutic efficacy rapidly …
antianginal agent. Unfortunately, after continuous application, its therapeutic efficacy rapidly …
Organic nitrate therapy, nitrate tolerance, and nitrate-induced endothelial dysfunction: emphasis on redox biology and oxidative stress
Organic nitrates, such as nitroglycerin (GTN), isosorbide-5-mononitrate and isosorbide
dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator …
dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator …
NO‐and haem‐independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle
Soluble guanylyl cyclase (sGC) is the only proven receptor for the ubiquitous biological
messenger nitric oxide (NO) and is intimately involved in many signal transduction …
messenger nitric oxide (NO) and is intimately involved in many signal transduction …
Physiology and pathophysiology of vascular signaling controlled by cyclic guanosine 3′, 5′-cyclic monophosphate–dependent protein kinase
defects, desensitization, or other aberrations in the pathways distal to NO/NPs must be
recognized as capable of derailing the desired procession of events. The ensuing …
recognized as capable of derailing the desired procession of events. The ensuing …
Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance
K Sydow, A Daiber, M Oelze, Z Chen… - The Journal of …, 2004 - Am Soc Clin Investig
Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a
central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo …
central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo …