Alzheimer's disease (AD) is a neurodegenerative disease with progressive dementia
accompanied by three main structural changes in the brain: diffuse loss of neurons; …

There is strong evidence that protein kinase C (PKC) isozyme signaling pathways are
causally involved in associative memory storage. Other observations have indicated that …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which is probably
caused by the cytotoxic effect of the amyloid β-peptide (Aβ). We report here molecular …

Alzheimer's disease (AD) characteristically presents with early memory loss. Regulation of
K+ channels, calcium homeostasis, and protein kinase C (PKC) activation are molecular …

Since the 1980s, the cholinergic hypothesis of the pathogenesis of Alzheimer's disease has
proven to be a strong stimulus to pharmacological strategies aimed at correcting the …

The ideal biomarker for Alzheimer's disease (AD) should detect a fundamental feature of
neuropathology and be validated in neuropathologically-confirmed cases; it should have a …

We have previously identified alterations of K+ channel function, IP3-mediated calcium
release, and Cp20 (a memory-associated GTP binding protein) in fibroblasts from …

Ischemic stroke and Alzheimer's disease (AD), despite being distinct disease entities, share
numerous pathophysiological mechanisms such as those mediated by inflammation …

The possibility that altered calcium (Caz+) regulation plays an important role in neuronal
aging and dementia has been a focus of research interest for about 15 years, and continues …

Alterations in amyloid precursor protein (APP) metabolism, calcium regulation, oxidative
metabolism, and transduction systems have been implicated in Alzheimer's disease (AD) …