Modeling molecular motors

F Jülicher, A Ajdari, J Prost - Reviews of Modern Physics, 1997 - APS
The authors present general considerations and simple models for the operation of
isothermal motors at small scales, in asymmetric environments. Their work is inspired by …

Toward intelligent molecular machines: directed motions of biological and artificial molecules and assemblies

K Kinbara, T Aida - Chemical reviews, 2005 - ACS Publications
In the last two decades, considerable progress has been made in the field of molecular
biology, which has enabled a molecular-level understanding of a number of interesting …

Direct observation of kinesin stepping by optical trapping interferometry

K Svoboda, CF Schmidt, BJ Schnapp, SM Block - Nature, 1993 - nature.com
Do biological motors move with regular steps? To address this question, we constructed
instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular …

Single myosin molecule mechanics: piconewton forces and nanometre steps

JT Finer, RM Simmons, JA Spudich - Nature, 1994 - nature.com
A new in vitro assay using a feedback enhanced laser trap system allows direct
measurement of force and displacement that results from the interaction of a single myosin …

Magnetic tweezers: micromanipulation and force measurement at the molecular level

C Gosse, V Croquette - Biophysical journal, 2002 - cell.com
Cantilevers and optical tweezers are widely used for micromanipulating cells or
biomolecules for measuring their mechanical properties. However, they do not allow easy …

Imaging of single fluorescent molecules and individual ATP turnovers by single myosin molecules in aqueous solution

T Funatsu, Y Harada, M Tokunaga, K Saito, T Yanagida - Nature, 1995 - nature.com
VISUALIZATION of single actin filaments by fluorescence microscopy1led to the
development of new in vitro assays for analysing actomyosin-based motility at the molecular …

Sensitive force technique to probe molecular adhesion and structural linkages at biological interfaces

E Evans, K Ritchie, R Merkel - Biophysical journal, 1995 - cell.com
Adhesion and cytoskeletal structure are intimately related in biological cell function. Even
with the vast amount of biological and biochemical data that exist, little is known at the …

Direct measurement of stiffness of single actin filaments with and without tropomyosin by in vitro nanomanipulation.

H Kojima, A Ishijima… - Proceedings of the …, 1994 - National Acad Sciences
In order to explain the molecular mechanism of muscle contraction, it is crucial to know the
distribution of the sarcomere compliance of active muscle. Here, we directly measure the …

From mechanical force to RhoA activation

EC Lessey, C Guilluy, K Burridge - Biochemistry, 2012 - ACS Publications
Throughout their lives, all cells constantly experience and respond to various mechanical
forces. These frequently originate externally but can also arise internally as a result of the …

Classic and contemporary approaches to modeling biochemical reactions

WW Chen, M Niepel, PK Sorger - Genes & development, 2010 - genesdev.cshlp.org
Recent interest in modeling biochemical networks raises questions about the relationship
between often complex mathematical models and familiar arithmetic concepts from classical …