The cancer spliceome: reprograming of alternative splicing in cancer

E El Marabti, I Younis - Frontiers in molecular biosciences, 2018 - frontiersin.org
Alternative splicing allows for the expression of multiple RNA and protein isoforms from one
gene, making it a major contributor to transcriptome and proteome diversification in …

NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age

GK Gray, BC McFarland, SE Nozell… - Expert review of …, 2014 - Taylor & Francis
Since we last addressed the roles of NF-κB and JAK/STAT3 signaling in glioblastoma (GBM)
5 years ago, tremendous strides have been made in the understanding of these two …

Development of T cells redirected to glypican-3 for the treatment of hepatocellular carcinoma

H Gao, K Li, H Tu, X Pan, H Jiang, B Shi, J Kong… - Clinical Cancer …, 2014 - AACR
Purpose: The aim of our study is to elucidate whether T cells expressing GPC3-targeted
chimeric antigen receptor (CAR) can efficiently eliminate GPC3-positive HCC cells and their …

Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors

R Burr, I Leshchiner, CL Costantino, M Blohmer… - Nature Cancer, 2024 - nature.com
Although the development of multiple primary tumors in smokers with lung cancer can be
attributed to carcinogen-induced field cancerization, the occurrence of multiple tumors at …

MicroRNA-210-3p is transcriptionally upregulated by hypoxia induction and thus promoting EMT and chemoresistance in glioma cells

H Liu, C Chen, J Zeng, Z Zhao, Q Hu - PLoS One, 2021 - journals.plos.org
Background Glioma is the most common and lethal form of brain cancer. It is highly
malignant and is often characterized by chemoresistance and radioresistance, which are …

M1 to M2 macrophage polarization in heparin-binding epidermal growth factor-like growth factor therapy for necrotizing enterocolitis

J Wei, GE Besner - Journal of Surgical Research, 2015 - Elsevier
Background Macrophages can be polarized into proinflammatory (M1) and anti-
inflammatory (M2) subtypes. However, whether macrophage polarization plays a role in …

Development of self-assembling peptide nanovesicle with bilayers for enhanced EGFR-targeted drug and gene delivery

X Liang, B Shi, K Wang, M Fan, D Jiao, J Ao, N Song… - Biomaterials, 2016 - Elsevier
Abstract Development of rational vectors for efficient drug and gene delivery is crucial for
cancer treatment. In this study, epidermal growth factor receptor (EGFR)-binding peptide …

Selective targeting of glioblastoma with EGFRvIII/EGFR bitargeted chimeric antigen receptor T cell

H Jiang, H Gao, J Kong, B Song, P Wang, B Shi… - Cancer immunology …, 2018 - AACR
The heterogeneous expression of EGFRvIII [variant III mutant of epidermal growth factor
receptor (EGFR)] in glioblastoma has significant impact on the clinical response to the …

miR-542-5p attenuates fibroblast activation by targeting integrin α6 in silica-induced pulmonary fibrosis

J Yuan, P Li, H Pan, Y Li, Q Xu, T Xu, X Ji, Y Liu… - International Journal of …, 2018 - mdpi.com
Silicosis is a very serious occupational disease and it features pathological manifestations of
inflammatory infiltration, excessive proliferation of fibroblasts and massive depositions of the …

Hypoxia activates enhanced invasive potential and endogenous hyaluronic acid production by glioblastoma cells

JWE Chen, J Lumibao, A Blazek, HR Gaskins… - Biomaterials …, 2018 - pubs.rsc.org
Glioblastoma (GBM) is the most common, aggressive, and deadly form of adult brain cancer,
and is associated with a short survival rate (median 12–15 months, 5+ year less than 5%) …