[HTML][HTML] Leishmaniasis in immunosuppressed individuals

J Van Griensven, E Carrillo, R López-Vélez… - Clinical Microbiology …, 2014 - Elsevier
Leishmaniasis is a vector-born chronic infectious disease caused by a group of protozoan
parasites of the genus Leishmania. Whereas most immunocompetent individuals will not …

Cysteine proteases in protozoan parasites

JL Siqueira-Neto, A Debnath, LI McCall… - PLoS neglected …, 2018 - journals.plos.org
Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites,
including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and …

Diagnosis of leishmaniasis

EK Elmahallawy, AS Martínez… - The Journal of Infection …, 2014 - jidc.org
Leishmaniasis is a clinically heterogeneous syndrome caused by intracellular protozoan
parasites of the genus Leishmania. The clinical spectrum of leishmaniasis encompasses …

A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing

WW Zhang, S Karmakar, S Gannavaram, R Dey… - Nature …, 2020 - nature.com
Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa transmitted
by infected sand flies. Vaccination through leishmanization with live Leishmania major has …

Global genome diversity of the Leishmania donovani complex

SU Franssen, C Durrant, O Stark, B Moser, T Downing… - Elife, 2020 - elifesciences.org
Protozoan parasites of the Leishmania donovani complex–L. donovani and L. infantum–
cause the fatal disease visceral leishmaniasis. We present the first comprehensive genome …

The role of eukaryotic and prokaryotic ABC transporter family in failure of chemotherapy

R El-Awady, E Saleh, A Hashim, N Soliman… - Frontiers in …, 2017 - frontiersin.org
Over the years chemotherapy failure has been a vital research topic as researchers have
been striving to discover reasons behind it. The extensive studies carried out on …

Chemical biology approaches to designing defined carbohydrate vaccines

C Anish, B Schumann, CL Pereira, PH Seeberger - Chemistry & biology, 2014 - cell.com
Carbohydrate antigens have shown promise as important targets for developing effective
vaccines and pathogen detection strategies. Modifying purified microbial glycans through …

Phlebotomine sand fly–borne pathogens in the Mediterranean Basin: Human leishmaniasis and phlebovirus infections

M Moriconi, G Rugna, M Calzolari… - PLoS neglected …, 2017 - journals.plos.org
Pathogens transmitted to humans by phlebotomine sand flies are neglected, as they cause
infectious diseases that are not on the priority list of national and international public health …

Leishmania treatment and prevention: Natural and synthesized drugs

AA Bekhit, E El-Agroudy, A Helmy, TM Ibrahim… - European journal of …, 2018 - Elsevier
Leishmaniasis affects over 150 million people all over the world, especially in subtropical
regions. Currently used antileishmanial synthesized drugs are associated with some …

Unusual observations in leishmaniasis—an overview

P Yadav, M Azam, V Ramesh, R Singh - Pathogens, 2023 - mdpi.com
Leishmaniasis significantly affects the population of the tropics and subtropics. Clinical
features and infective species of Leishmania are the primary factors driving the direction of …