The spatial and temporal organization of molecules within a cell is critical for coordinating
the many distinct activities carried out by the cell. In an increasing number of biological …

Bacterial pathogens operate by attacking crucial intracellular pathways in their hosts. These
pathogens usually target more than one intracellular pathway and often interact at several …

Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by homozygous
or compound heterozygous gain-of-function mutations in MEFV, which encodes pyrin, an …

A type III secretion system (TTSS) is encoded on a virulence plasmid that is common to three
pathogenic Yersinia species: Y. enterocolitica, Y. pseudotuberculosis, and Y. pestis …

Living cells display complex signal processing behaviors, many of which are mediated by
networks of proteins specialized for signal transduction. Here we focus on the question of …

Rhizobia—a diverse group of soil bacteria—induce the formation of nitrogen-fixing nodules
on the roots of legumes. Nodulation begins when the roots initiate a molecular dialogue with …

Pathogenic Yersinia, including Y. pestis, the agent of plague in humans, and Y.
pseudotuberculosis, the related enteric pathogen, deliver virulence effectors into host cells …

Inflammasome assembly activates caspase-1 and initiates the inflammatory cell death
program pyroptosis, which is protective against numerous pathogens. Consequently …

Many bacteria pathogenic for plants or animals, including Shigella spp., which is
responsible for shigellosis in humans, use a type III secretion apparatus to inject effector …

To overcome host defenses, bacterial pathogens of the genus Yersinia inject specific
effector proteins into colonized mammalian cells. One such virulence factor, YopJ, inhibits …