The ability of bacteria to adhere to each other and both biotic and abiotic surfaces is key to
biofilm formation, and one way that bacteria adhere is using fibrillar adhesins. Fibrillar …

Background A Lactobacillus-dominated vaginal microbiome provides the first line of defense
against adverse genital tract health outcomes. However, there is limited understanding of …

Numerous bacteria naturally occur within spatially organised, multicellular communities
called biofilms. Moreover, most bacterial infections proceed with biofilm formation, posing …

Staphylococcus aureus and Staphylococcus epidermidis are frequently associated with
medical device infections that involve establishment of a bacterial biofilm on the device …

Multidrug-resistant (MDR) Enterococcus faecalis are major causes of hospital-acquired
infections. Numerous clinical strains of E. faecalis harbor a large pathogenicity island that …

Fibrillar adhesins are bacterial cell surface proteins that mediate interactions with the
environment, including host cells during colonization or other bacteria during biofilm …

Many oral bacteria employ cell wall-anchored adhesins to bind to the salivary films coating
the teeth and mucosal surfaces. Surface binding prevents clearance and facilitates …

Background Fibrillar adhesins are long multidomain proteins that form filamentous structures
at the cell surface of bacteria. They are an important yet understudied class of proteins …

Bacteria sense, interact with, and modify their environmental niche by deploying a molecular
ensemble at the cell surface. The changeability of this exposed interface, combined with …

Background Streptococcus pneumoniae (pneumococcus) represents an important human
pathogen, responsible for respiratory and invasive infections in the community. The efficacy …