Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

Macrophages are the most important phagocytes in vivo. However, the tumor
microenvironment can affect the function and polarization of macrophages and form tumor …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. PDAC is only
cured by surgical resection in its early stage, but there remains a relatively high possibility of …

The trillions of microorganisms in the gut microbiome have attracted much attention recently
owing to their sophisticated and widespread impacts on numerous aspects of host …

The past decade has witnessed groundbreaking advances in the field of microbiome
research. An area where immense implications of the microbiome have been demonstrated …

Microbial communities and human cells, through a dynamic crosstalk, maintain a mutualistic
relationship that contributes to the maintenance of cellular metabolism and of the immune …

Liver metastasis is the major cause of death in colorectal cancer (CRC) patients.
Nevertheless, the underlying mechanisms remain unknown. Gut microbiota intricately affect …

Long known as digestive organelles, lysosomes have now emerged as multifaceted centers
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …

Simple Summary The gut microbiome affects the development of systemic immune response
and it can also impact response to systemic treatments such as immunotherapy and …