The maintenance and preservation of distinct phases during the cell cycle is a highly
complex and coordinated process. It is regulated by phosphorylation—through the activity of …

In normal prostate, neuroendocrine (NE) cells are rare and interspersed among the
epithelium. These cells are believed to provide trophic signals to epithelial cell populations …

MicroRNAs (miRNAs) are implicated in both tissue differentiation and maintenance of tissue
identity. In most cases, however, the mechanisms underlying their regulation are not known …

Neuroblastoma is an embryonal malignancy of the sympathetic nervous system.
Spontaneous regression and differentiation of neuroblastoma is observed in a subset of …

Transcriptional regulation is a critical mechanism in the birth, specification, and
differentiation of granule neurons in the adult hippocampus. One of the first negative-acting …

Protein complexes that contain chromatin-modifying enzymes have an important role in
regulating gene expression. Recent studies have shown that a single transcription factor, the …

Glioblastomas (GBMs) are highly lethal primary brain tumors. Despite current therapeutic
advances in other solid cancers, the treatment of these malignant gliomas remains …

The neuronal repressor REST (RE1-silencing transcription factor; also called NRSF) is
expressed at high levels in mouse embryonic stem (ES) cells, but its role in these cells is …

We previously obtained evidence for reduced cell proliferation in the dentate gyrus (DG) of
fetuses with Down syndrome (DS), suggesting that the hippocampal hypoplasia seen in …

Medulloblastoma is an aggressive brain malignancy with high incidence in childhood.
Current treatment approaches have limited efficacy and severe side effects. Therefore, new …