The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Matrix metalloproteinases (MMPs) are zinc‐dependent endopeptidases that were first
discovered as proteases, which target and cleave extracellular proteins. During the past 20 …

Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

Biomarkers are used as tools in cancer diagnostics and in treatment stratification. In most
cancers, there are increased levels of one or several members of the matrix …

Proteases have long been associated with cancer progression because of their ability to
degrade extracellular matrices, which facilitates invasion and metastasis. However, recent …

Matrix metalloproteinases (MMPs) are reputed to cause the inflammatory tissue destruction
characterizing chronic inflammatory diseases and to degrade basement membrane …

The activity of matrix metalloproteinases (MMPs) is regulated at several levels, including
enzyme activation, inhibition, complex formation and compartmentalization. Regulation at …

Abstract Background Matrix metalloproteinases (MMPs) are a family of structural and
functional related endopeptidases. They play a crucial role in tumor invasion and building of …

Adaption of a single protein to perform multiple independent functions facilitates functional
plasticity of the proteome allowing a limited number of protein-coding genes to perform a …

Background Matrix metalloproteinases (MMPs) are regarded to be relevant to the prognosis
of breast cancer. Numerous studies have confirmed the association between MMPs and …