Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK)
cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four …

Mitogen-activated protein kinase dual-specificity phosphatase-1 (also called MKP-1,
DUSP1, ERP, CL100, HVH1, PTPN10, and 3CH134) is a member of the threonine-tyrosine …

The MEK5/ERK5 mitogen-activated protein kinases (MAPK) cascade is a unique signaling
module activated by both mitogens and stress stimuli, including cytokines, fluid shear stress …

Extracellular-regulated protein kinase 5 (ERK5) is a mitogen-activated protein kinase
(MAPK) regulated by a wide range of mitogens and cellular stresses. Since its cloning in …

The Kruppel-like factor 2 (KLF2) and Kruppel-like factor 4 (KLF4) transcription factors have
recently been shown to act as critical regulators of endothelial homeostasis. While several …

WNK1 belongs to a unique protein kinase family that lacks the catalytic lysine in its normal
position. Mutations in human WNK1 and WNK4 have been implicated in causing a familial …

The mitogen-activated protein kinase (MAPK) cascades transmit signals from extracellular
stimuli to a variety of distinct cellular processes. The MAPKKs in each cascade specifically …

Signal transduction pathways in eukaryotic cells integrate diverse extracellular signals, and
regulate complex biological responses such as growth, differentiation and death. One group …

Simple Summary Alterations of the MEK5/ERK5 signaling pathway have been described in
several tumors, and emerging data are trying to explain the complexity of ERK5-related …

Peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors
that form a subfamily of the nuclear receptor gene family. Since both flow and PPARγ have …