Nanoparticle-based delivery systems for vaccines

R Bezbaruah, VP Chavda, L Nongrang, S Alom… - Vaccines, 2022 - mdpi.com
Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional
vaccinations may have low immunogenicity and, in most situations, only provide partial …

Biomaterials for vaccine-based cancer immunotherapy

R Zhang, MM Billingsley, MJ Mitchell - Journal of Controlled Release, 2018 - Elsevier
The development of therapeutic cancer vaccines as a means to generate immune reactivity
against tumors has been explored since the early discovery of tumor-specific antigens by …

Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening

PPG Guimaraes, R Zhang, R Spektor, M Tan… - Journal of Controlled …, 2019 - Elsevier
Messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapy,
with the potential to induce protein production to treat and prevent a range of diseases …

Nanoparticles for nucleic acid delivery: Applications in cancer immunotherapy

AJ Mukalel, RS Riley, R Zhang, MJ Mitchell - Cancer letters, 2019 - Elsevier
Immunotherapy has recently emerged as a powerful tool for cancer treatment. Early clinical
successes from cancer immunotherapy have led to a growing list of FDA approvals, and …

Synthetic charge-invertible polymer for rapid and complete implantation of layer-by-layer microneedle drug films for enhanced transdermal vaccination

Y He, C Hong, J Li, MLT Howard, Y Li, ME Turvey… - ACS …, 2018 - ACS Publications
The utility of layer-by-layer (LbL) coated microneedle (MN) skin patches for transdermal drug
delivery has proven to be a promising approach, with advantages over hypodermal injection …

Peptide amphiphile micelle vaccine size and charge influence the host antibody response

R Zhang, JD Smith, BN Allen, JS Kramer… - ACS Biomaterials …, 2018 - ACS Publications
Vaccines are one of the best health care advances ever developed, having led to the
eradication of smallpox and near eradication of polio and diphtheria. While tremendously …

Vaccine adjuvant incorporation strategy dictates peptide amphiphile micelle immunostimulatory capacity

R Zhang, JS Kramer, JD Smith, BN Allen, CN Leeper… - The AAPS journal, 2018 - Springer
Current vaccine research has shifted from traditional vaccines (ie, whole-killed or live-
attenuated) to subunit vaccines (ie, protein, peptide, or DNA) as the latter is much safer due …

Immunomodulatory vasoactive intestinal peptide amphiphile micelles

R Zhang, CN Leeper, X Wang, TA White… - Biomaterials …, 2018 - pubs.rsc.org
Two different vasoactive intestinal peptide (VIP) amphiphiles have been formulated which
readily form micelles of varying shapes. Interestingly, VIP micelle structure has been found …

Instructive design of triblock peptide amphiphiles for structurally complex micelle fabrication

R Zhang, LD Morton, JD Smith, F Gallazzi… - ACS Biomaterials …, 2018 - ACS Publications
Hydrophobically driven self-assembly is a well-understood principle that has been shown to
facilitate micelle formation. Although quite useful, the library of structures accessible is …

Synthetic peptides derived from predicted B cell epitopes of nervous necrosis virus (NNV) show antigenicity and elicit immunogenic responses in Asian seabass …

SV Jungi, VI Machimbirike, NV Linh… - Fish & Shellfish …, 2023 - Elsevier
Nervous necrosis virus (NNV) has spread throughout the world, affecting more than 120
freshwater and marine fish species. While vaccination effectively prevents disease …