Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment

H Tian, J Cao, B Li, EC Nice, H Mao, Y Zhang… - Bone Research, 2023 - nature.com
Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

TGF-β signaling networks in the tumor microenvironment

MKK Chan, JYF Chung, PCT Tang, ASW Chan, JYY Ho… - Cancer letters, 2022 - Elsevier
Transforming growth factor-β (TGF-β) signaling shows important roles in both physiology
and pathology, especially in the progression of inflammatory diseases including cancer …

The correlation between cancer stem cells and epithelial-mesenchymal transition: molecular mechanisms and significance in cancer theragnosis

ZN Lei, QX Teng, J Koya, Y Liu, Z Chen… - Frontiers in …, 2024 - frontiersin.org
The connections between cancer stem cells (CSCs) and epithelial-mesenchymal transition
(EMT) is critical in cancer initiation, progression, metastasis, and therapy resistance, making …

Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation

C van Geffen, C Heiss, A Deißler… - Frontiers in …, 2022 - frontiersin.org
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent
suppressive and regulative properties. MDSCs' strong immunosuppressive potential creates …

Inflammatory networks in renal cell carcinoma

L Kruk, M Mamtimin, A Braun, HJ Anders, J Andrassy… - Cancers, 2023 - mdpi.com
Simple Summary Inflammation is an important hallmark of advanced renal cell carcinoma
and plays a pivotal role in tumor progression, metastasis, and anti-cancer resistance …

Pirfenidone inhibits TGF‐β1‐induced metabolic reprogramming during epithelial‐mesenchymal transition in non‐small cell lung cancer

S Zhang, Y Wang, D Luo, Z Cheng… - Journal of Cellular …, 2024 - Wiley Online Library
Metastasis is an important contributor to increased mortality rates in non‐small cell lung
cancer (NSCLC). The TGF‐β signalling pathway plays a crucial role in facilitating tumour …

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition

A Glaviano, HSH Lau, LM Carter, EHC Lee… - Journal of Hematology & …, 2025 - Springer
The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis
and treatment response. It consists of diverse cell types, extracellular matrix components …

[HTML][HTML] Cancer-educated neutrophils promote lung cancer progression via PARP-1-ALOX5-mediated MMP-9 expression

L Han, Y Chen, N Huang, X Zhou, Y Lv… - Cancer Biology & …, 2024 - ncbi.nlm.nih.gov
Objective: Neutrophils are one of the most predominant infiltrating leukocytes in lung cancer
tissues and are associated with lung cancer progression. How neutrophils promote lung …

[HTML][HTML] Research progress of nanomaterials in tumor-targeted drug delivery and imaging therapy

LR Fang, YH Wang, ZZ Xiong, YM Wang - OpenNano, 2023 - Elsevier
Cancer continues to threaten people's lives and health, and the number of deaths from
cancer is very high each year. Traditional treatments such as chemotherapy and surgery are …

Suspended particulate matter promotes epithelial-to-mesenchymal transition in alveolar epithelial cells via TGF-β1-mediated ROS/IL-8/SMAD3 axis

S Molavinia, D Dayer, MJ Khodayar, G Goudarzi… - Journal of …, 2024 - Elsevier
Epidemiological evidence presents that dust storms are related to respiratory diseases, such
as pulmonary fibrosis (PF). However, the precise underlying mechanisms of SPM-elicited …