Recent progress in mass spectrometry proteomics for biomedical research
Proteins are the key players in many cellular processes. Their composition, trafficking, and
interactions underlie the dynamic processes of life. Furthermore, diseases are frequently …
interactions underlie the dynamic processes of life. Furthermore, diseases are frequently …
[HTML][HTML] A mouse model to test novel therapeutics for Parkinson's disease: an update on the Thy1-aSyn (“line 61”) mice
F Richter, M Stanojlovic, C Käufer, B Gericke, M Feja - Neurotherapeutics, 2023 - Elsevier
Abstract Development of neuroprotective therapeutics for Parkinson's disease (PD) is facing
a lack of translation from pre-clinical to clinical trials. One strategy for improvement is to …
a lack of translation from pre-clinical to clinical trials. One strategy for improvement is to …
[HTML][HTML] Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of …
Murine studies showed that disruption of circadian clock rhythmicity could lead to cancer
and metabolic syndrome. Time-restricted feeding can reset the disrupted clock rhythm …
and metabolic syndrome. Time-restricted feeding can reset the disrupted clock rhythm …
Myocardial Rev-erb–mediated diurnal metabolic rhythm and obesity paradox
Background: The nuclear receptor Rev-erbα/β, a key component of the circadian clock,
emerges as a drug target for heart diseases, but the function of cardiac Rev-erb has not …
emerges as a drug target for heart diseases, but the function of cardiac Rev-erb has not …
Subcellular proteomics of dopamine neurons in the mouse brain
Dopaminergic neurons modulate neural circuits and behaviors via dopamine (DA) release
from expansive, long range axonal projections. The elaborate cytoarchitecture of these …
from expansive, long range axonal projections. The elaborate cytoarchitecture of these …
Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor
Asprosin is a fasting-induced glucogenic and centrally acting orexigenic hormone. The
olfactory receptor Olfr734 is known to be the hepatic receptor for asprosin that mediates its …
olfactory receptor Olfr734 is known to be the hepatic receptor for asprosin that mediates its …
[HTML][HTML] The clock modulator Nobiletin mitigates astrogliosis‐associated neuroinflammation and disease hallmarks in an Alzheimer's disease model
Alzheimer's disease (AD) is a devastating neurodegenerative disorder, and there is a
pressing need to identify disease‐modifying factors and devise interventional strategies. The …
pressing need to identify disease‐modifying factors and devise interventional strategies. The …
gpGrouper: a peptide grouping algorithm for gene-centric inference and quantitation of bottom-up proteomics data
AB Saltzman, M Leng, B Bhatt, P Singh… - Molecular & Cellular …, 2018 - ASBMB
In quantitative mass spectrometry, the method by which peptides are grouped into proteins
can have dramatic effects on downstream analyses. Here we describe gpGrouper, an …
can have dramatic effects on downstream analyses. Here we describe gpGrouper, an …
In-depth mapping of protein localizations in whole tissue by micro-scaffold assisted spatial proteomics (MASP)
Accurate, in-depth mapping of proteins on whole-tissue levels provides comprehensive
insights into the spatially-organized regulatory processes/networks in tissues, but is …
insights into the spatially-organized regulatory processes/networks in tissues, but is …
Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice
DL Galvan, J Long, N Green, BH Chang… - The Journal of …, 2019 - Am Soc Clin Investig
Phosphorylation of dynamin-related protein 1 (Drp1) represents an important regulatory
mechanism for mitochondrial fission. Here, we established the role of Drp1 serine 600 …
mechanism for mitochondrial fission. Here, we established the role of Drp1 serine 600 …