Rapid screening of acetylcholinesterase inhibitors in Qi-Fu-Yin using magnetic metal–organic frameworks immobilized with acetylcholinesterase

H Li, H Zhao, L Chen, W Zhang, W Zhang, X Cheng - Bioorganic Chemistry, 2025 - Elsevier
Current immobilization approaches for ligand fishing often experience challenges such as
limited protein loading capacity and difficulties in the recycling process. To overcome these …

Biologically Active Ammonium Isatin-3-acylhydrazones Bearing Long-Chain Alkyl Substituent of Various Structures

AV Bogdanov, AV Samorodov, ZA Valiullina… - Russian Journal of …, 2024 - Springer
New ammonium hydrazones have been synthesized by the reaction of Girard's reagents T
and P with isatin derivatives that contain various alkyl or geranyl substituents in position 1. A …

ACETYLCHOLINESTERASE, TYROSINASE AND PEROXIREDOXIN ENZYME INHIBITORY ACTIVITY STUDIES OF SYNTHESISED OXADIAZOLES AND …

JP JAMES, KP Shettigar - Bulletin of Pharmaceutical …, 2024 - bpsa.journals.ekb.eg
With the increasing prevalence of neurodegenerative diseases (NDDs) and the limited
effectiveness of existing treatments, there is a pressing need to discover new therapeutic …

In silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel reactivators of acetylcholinesterase inhibited by an A-230 surrogate

L Bernardo, L Vieira, C Borges, P Buitrago, K Kuča… - 2024 - chemrxiv.org
Recent events involving A-series nerve agents, a once elusive class of chemical warfare
agents, have provoked a great concern in the international community. In this paper …