In order to maintain genomic stability, cells have developed sophisticated signalling
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …

Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …

Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …

The DNA damage response (DDR) represents a complex network of proteins which detect
and repair DNA damage, thereby maintaining the integrity of the genome and preventing the …

Over the last decade the unravelling of the molecular mechanisms of the DNA damage
response pathways and of the genomic landscape of human tumors have paved the road to …

Synthetic lethality occurs when simultaneous perturbations of two genes or molecular
processes result in a loss of cell viability. The number of known synthetically lethal …

FEN1 has key roles in Okazaki fragment maturation during replication, long patch base
excision repair, rescue of stalled replication forks, maintenance of telomere stability and …

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors have raised high expectations for
the treatment of multiple malignancies. PARP inhibitors, which can be used as …

DNA single-strand breaks (SSBs) arise as a consequence of spontaneous DNA instability
and are also formed as DNA repair intermediates. Their repair is critical because they …

Abstract Treatment for advanced ovarian cancer is rarely curative; three quarters of patients
with advanced disease relapse and ultimately die with resistant disease. Improving patient …